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Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death

OBJECTIVE: To assess the effect of an incremental increase in faecal haemoglobin (f-Hb) concentration on colorectal cancer (CRC) mortality and all-cause death. DESIGN: We conducted an observational study of cohorts over time based on two population-based CRC screening programmes. SETTING: Two cities...

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Autores principales: Chen, Li-Sheng, Yen, Amy Ming-Fang, Fraser, Callum G, Chiu, Sherry Yueh-Hsia, Fann, Jean Ching-Yuan, Wang, Po-En, Lin, Sheng-Che, Liao, Chao-Sheng, Lee, Yi-Chia, Chiu, Han-Mo, Chen, Hsiu-Hsi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822305/
https://www.ncbi.nlm.nih.gov/pubmed/24202058
http://dx.doi.org/10.1136/bmjopen-2013-003740
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author Chen, Li-Sheng
Yen, Amy Ming-Fang
Fraser, Callum G
Chiu, Sherry Yueh-Hsia
Fann, Jean Ching-Yuan
Wang, Po-En
Lin, Sheng-Che
Liao, Chao-Sheng
Lee, Yi-Chia
Chiu, Han-Mo
Chen, Hsiu-Hsi
author_facet Chen, Li-Sheng
Yen, Amy Ming-Fang
Fraser, Callum G
Chiu, Sherry Yueh-Hsia
Fann, Jean Ching-Yuan
Wang, Po-En
Lin, Sheng-Che
Liao, Chao-Sheng
Lee, Yi-Chia
Chiu, Han-Mo
Chen, Hsiu-Hsi
author_sort Chen, Li-Sheng
collection PubMed
description OBJECTIVE: To assess the effect of an incremental increase in faecal haemoglobin (f-Hb) concentration on colorectal cancer (CRC) mortality and all-cause death. DESIGN: We conducted an observational study of cohorts over time based on two population-based CRC screening programmes. SETTING: Two cities of Taiwan. PARTICIPANTS: 1233 individuals with CRC (217 prevalent cases and 1016 incident cases) and 2640 with colorectal adenoma (1246 prevalent cases and 1394 incident cases) found in the two cohorts of 59 767 and 125 976 apparently healthy individuals, aged 40 years and above, who had been invited to participate in screening since 2001 and 2003, respectively. MAIN OUTCOME MEASURES: Death from CRC and all-cause death ascertained by following up from the entire two cohorts over time until 2009. RESULTS: The effect of an incremental increase in f-Hb on the risk for CRC mortality was noted, increasing from a slightly increased risk for the category of f-Hb of 20–49 ng Hb/mL (adjusted HR (aHR)=1.09; 95% CI 0.68 to 1.75) to 11.67 (95% CI 7.71 to 17.66) for the group with f-Hb≥450 ng Hb/mL as compared with the group considered baseline with f-Hb of 1–19 ng Hb/mL (p<0.001). A similar but less marked increasing trend was found for all-cause mortality, aHR increasing from 1.15 (95% CI 1.07 to 1.24) for the group with f-Hb of 20–49 ng Hb/mL to 1.67 (95% CI 1.54 to 2.07) for the group with f-Hb≥450 ng Hb/mL. CONCLUSIONS: We substantiated the impacts of an incremental increase in f-Hb on the risk for death from CRC and all-cause death, consistently showing a significant gradient relationship. Both discoveries suggest that f-Hb may not only make contribution to facilitating individually tailored screening for CRC but also can be used as a significant predictor for life expectancy.
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spelling pubmed-38223052013-11-12 Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death Chen, Li-Sheng Yen, Amy Ming-Fang Fraser, Callum G Chiu, Sherry Yueh-Hsia Fann, Jean Ching-Yuan Wang, Po-En Lin, Sheng-Che Liao, Chao-Sheng Lee, Yi-Chia Chiu, Han-Mo Chen, Hsiu-Hsi BMJ Open Epidemiology OBJECTIVE: To assess the effect of an incremental increase in faecal haemoglobin (f-Hb) concentration on colorectal cancer (CRC) mortality and all-cause death. DESIGN: We conducted an observational study of cohorts over time based on two population-based CRC screening programmes. SETTING: Two cities of Taiwan. PARTICIPANTS: 1233 individuals with CRC (217 prevalent cases and 1016 incident cases) and 2640 with colorectal adenoma (1246 prevalent cases and 1394 incident cases) found in the two cohorts of 59 767 and 125 976 apparently healthy individuals, aged 40 years and above, who had been invited to participate in screening since 2001 and 2003, respectively. MAIN OUTCOME MEASURES: Death from CRC and all-cause death ascertained by following up from the entire two cohorts over time until 2009. RESULTS: The effect of an incremental increase in f-Hb on the risk for CRC mortality was noted, increasing from a slightly increased risk for the category of f-Hb of 20–49 ng Hb/mL (adjusted HR (aHR)=1.09; 95% CI 0.68 to 1.75) to 11.67 (95% CI 7.71 to 17.66) for the group with f-Hb≥450 ng Hb/mL as compared with the group considered baseline with f-Hb of 1–19 ng Hb/mL (p<0.001). A similar but less marked increasing trend was found for all-cause mortality, aHR increasing from 1.15 (95% CI 1.07 to 1.24) for the group with f-Hb of 20–49 ng Hb/mL to 1.67 (95% CI 1.54 to 2.07) for the group with f-Hb≥450 ng Hb/mL. CONCLUSIONS: We substantiated the impacts of an incremental increase in f-Hb on the risk for death from CRC and all-cause death, consistently showing a significant gradient relationship. Both discoveries suggest that f-Hb may not only make contribution to facilitating individually tailored screening for CRC but also can be used as a significant predictor for life expectancy. BMJ Publishing Group 2013-11-06 /pmc/articles/PMC3822305/ /pubmed/24202058 http://dx.doi.org/10.1136/bmjopen-2013-003740 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Epidemiology
Chen, Li-Sheng
Yen, Amy Ming-Fang
Fraser, Callum G
Chiu, Sherry Yueh-Hsia
Fann, Jean Ching-Yuan
Wang, Po-En
Lin, Sheng-Che
Liao, Chao-Sheng
Lee, Yi-Chia
Chiu, Han-Mo
Chen, Hsiu-Hsi
Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title_full Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title_fullStr Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title_full_unstemmed Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title_short Impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
title_sort impact of faecal haemoglobin concentration on colorectal cancer mortality and all-cause death
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822305/
https://www.ncbi.nlm.nih.gov/pubmed/24202058
http://dx.doi.org/10.1136/bmjopen-2013-003740
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