Molecular mechanism of regulation of the calcium-binding protein calbindin-D(9k),and its physiological role(s) in mammals: a review of current research

Calbindin-D(9k) (CaBP-9k) is a cytosolic calcium-binding protein that is expressed in a variety of tissues, such as uterus, placenta, intestine, kidney, pituitary gland and bone. At present, the precise role(s) of CaBP-9k remains to be clarified. CaBP-9k-null mice are normal, which indicates that other calcium-transporter genes can compensate for the lack CaBP-9k. Uterine CaBP-9k has been shown to be involved in the regulation of myometrial activity by intracellular calcium. In the uterus and placenta, CaBP-9k expression is regulated by the sex steroid hormones oestrogen (E2) and progesterone (P4). Intestinal CaBP-9k is involved in intestinal calcium absorption, and is regulated at the transcriptional and post-transcriptional levels by 1,25-dihydroxyvitamin D3, the hormonal form of vitamin D. Thus, evidence to date suggests that CaBP-9k may be regulated in a tissue-specific manner. In this review, we will summarize current data on the molecular mechanism of regulation of CaBP-9k in mammals, including recent research data generated in our laboratories.