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Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours?
Several recent reports suggest that inflammatory signals play a decisive role in the self-renewal, migration and differentiation of multipotent neural stem cells (NSCs). NSCs are believed to be able to ameliorate the symptoms of several brain pathologies through proliferation, migration into the are...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822535/ https://www.ncbi.nlm.nih.gov/pubmed/18182066 http://dx.doi.org/10.1111/j.1582-4934.2007.00208.x |
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author | Widera, D Kaus, A Kaltschmidt, C Kaltschmidt, B |
author_facet | Widera, D Kaus, A Kaltschmidt, C Kaltschmidt, B |
author_sort | Widera, D |
collection | PubMed |
description | Several recent reports suggest that inflammatory signals play a decisive role in the self-renewal, migration and differentiation of multipotent neural stem cells (NSCs). NSCs are believed to be able to ameliorate the symptoms of several brain pathologies through proliferation, migration into the area of the lesion and either differentiation into the appropriate cell type or secretion of anti-inflammatory cytokines. Although NSCs have beneficial roles, current evidence indicates that brain tumours, such as astrogliomas or ependymomas are also caused by tumour-initiating cells with stem-like properties. However, little is known about the cellular and molecular processes potentially generating tumours from NSCs. Most pro-inflammatory conditions are considered to activate the transcription factor NF-κB in various cell types. Strong inductive effects of NF-κB on proliferation and migration of NSCs have been described. Moreover, NF-κB is constitutively active in most tumour cells described so far. Chronic inflammation is also known to initiate cancer. Thus, NF-κB might provide a novel mechanistic link between chronic inflammation, stem cells and cancer. This review discusses the apparently ambivalent role of NF-κB: physiological maintenance and repair of the brain via NSCs, and a potential role in tumour initiation. Furthermore, it reveals a possible mechanism of brain tumour formation based on inflammation and NF-κB activity in NSCs. |
format | Online Article Text |
id | pubmed-3822535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38225352015-04-27 Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? Widera, D Kaus, A Kaltschmidt, C Kaltschmidt, B J Cell Mol Med Reviews Several recent reports suggest that inflammatory signals play a decisive role in the self-renewal, migration and differentiation of multipotent neural stem cells (NSCs). NSCs are believed to be able to ameliorate the symptoms of several brain pathologies through proliferation, migration into the area of the lesion and either differentiation into the appropriate cell type or secretion of anti-inflammatory cytokines. Although NSCs have beneficial roles, current evidence indicates that brain tumours, such as astrogliomas or ependymomas are also caused by tumour-initiating cells with stem-like properties. However, little is known about the cellular and molecular processes potentially generating tumours from NSCs. Most pro-inflammatory conditions are considered to activate the transcription factor NF-κB in various cell types. Strong inductive effects of NF-κB on proliferation and migration of NSCs have been described. Moreover, NF-κB is constitutively active in most tumour cells described so far. Chronic inflammation is also known to initiate cancer. Thus, NF-κB might provide a novel mechanistic link between chronic inflammation, stem cells and cancer. This review discusses the apparently ambivalent role of NF-κB: physiological maintenance and repair of the brain via NSCs, and a potential role in tumour initiation. Furthermore, it reveals a possible mechanism of brain tumour formation based on inflammation and NF-κB activity in NSCs. Blackwell Publishing Ltd 2008-04 2007-12-20 /pmc/articles/PMC3822535/ /pubmed/18182066 http://dx.doi.org/10.1111/j.1582-4934.2007.00208.x Text en ©2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Widera, D Kaus, A Kaltschmidt, C Kaltschmidt, B Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title | Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title_full | Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title_fullStr | Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title_full_unstemmed | Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title_short | Neural stem cells, inflammation and NF-κB: basic principle of maintenance and repair or origin of brain tumours? |
title_sort | neural stem cells, inflammation and nf-κb: basic principle of maintenance and repair or origin of brain tumours? |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822535/ https://www.ncbi.nlm.nih.gov/pubmed/18182066 http://dx.doi.org/10.1111/j.1582-4934.2007.00208.x |
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