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MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition

The macrolide compound MFTZ-1 has been identified as a novel topoisomerase II (Top2) inhibitor with potent in vitro and in vivo anti-tumour activities. In this study, we further examined the effects of MFTZ-1 on hypoxia-inducible factor-1α (HIF-1α) accumulation, vascular endothelial growth factor (V...

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Detalles Bibliográficos
Autores principales:	Dai, Mei, Miao, Ze-Hong, Ren, Xuan, Tong, Lin-Jiang, Yang, Na, Li, Ting, Lin, Li-Ping, Shen, Yue-Mao, Ding, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822569/ https://www.ncbi.nlm.nih.gov/pubmed/19538463 http://dx.doi.org/10.1111/j.1582-4934.2009.00822.x

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