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miR-193 expression differentiates telocytes from other stromal cells
Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) si...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822620/ https://www.ncbi.nlm.nih.gov/pubmed/21447044 http://dx.doi.org/10.1111/j.1582-4934.2011.01325.x |
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author | Cismasiu, VB Radu, E Popescu, LM |
author_facet | Cismasiu, VB Radu, E Popescu, LM |
author_sort | Cismasiu, VB |
collection | PubMed |
description | Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells. |
format | Online Article Text |
id | pubmed-3822620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38226202015-04-06 miR-193 expression differentiates telocytes from other stromal cells Cismasiu, VB Radu, E Popescu, LM J Cell Mol Med Short Communication Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR-193 is differentially expressed between TCs and other interstitial cells. Because miR-193 regulates c-kit, our data support the previous finding that TCs express c-kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells (e.g. miR-133a, miR-208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells. Blackwell Publishing Ltd 2011-05 2011-05-26 /pmc/articles/PMC3822620/ /pubmed/21447044 http://dx.doi.org/10.1111/j.1582-4934.2011.01325.x Text en © 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Short Communication Cismasiu, VB Radu, E Popescu, LM miR-193 expression differentiates telocytes from other stromal cells |
title | miR-193 expression differentiates telocytes from other stromal cells |
title_full | miR-193 expression differentiates telocytes from other stromal cells |
title_fullStr | miR-193 expression differentiates telocytes from other stromal cells |
title_full_unstemmed | miR-193 expression differentiates telocytes from other stromal cells |
title_short | miR-193 expression differentiates telocytes from other stromal cells |
title_sort | mir-193 expression differentiates telocytes from other stromal cells |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822620/ https://www.ncbi.nlm.nih.gov/pubmed/21447044 http://dx.doi.org/10.1111/j.1582-4934.2011.01325.x |
work_keys_str_mv | AT cismasiuvb mir193expressiondifferentiatestelocytesfromotherstromalcells AT radue mir193expressiondifferentiatestelocytesfromotherstromalcells AT popesculm mir193expressiondifferentiatestelocytesfromotherstromalcells |