The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells

Histone deacetylase inhibitors (HDACi) induce tumour cell cycle arrest and/or apoptosis, and some of them are currently used in cancer therapy. Recently, we described a series of powerful HDACi characterized by a 1,4-benzodiazepine (BDZ) ring hybridized with a linear alkyl chain bearing a hydroxamat...

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Detalles Bibliográficos
Autores principales: Cellai, C, Balliu, M, Laurenzana, A, Guandalini, L, Matucci, R, Miniati, D, Torre, E, Nebbioso, A, Carafa, V, Altucci, L, Romanelli, M N, Paoletti, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822689/
https://www.ncbi.nlm.nih.gov/pubmed/22004558
http://dx.doi.org/10.1111/j.1582-4934.2011.01464.x

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