Cargando…

The relationship between early embryo development and tumourigenesis

With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Yanlei, Zhang, Peng, Wang, Feng, Yang, Jianjun, Yang, Zhe, Qin, Huanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822720/
https://www.ncbi.nlm.nih.gov/pubmed/21029369
http://dx.doi.org/10.1111/j.1582-4934.2010.01191.x
Descripción
Sumario:With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin of tumour, and the similarities between early embryo development and tumourigenesis with respect to cell invasive behaviours, epigenetic regulation, gene expression, protein profiling and other important biological behaviours. Given an improved understanding of the relationship between early embryo development and tumourigenesis, now we have better and broader resources to attack cancer from the perspective of developmental biology and develop next generation of prognostic and therapeutic approaches for this devastating disease.