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Evidence for the prevention of enthesitis in HLA-B27/hβ(2)m transgenic rats treated with a monoclonal antibody against TNF-α

Transgenic rats with high expression of HLA-B27 and human β(2)-microglobulin (B27TR) develop a multisystem inflammatory disease resembling human inflammatory bowel disease (IBD) and spondyloarthropaties (SpA). Tumour necrosis factor α (TNF-α) has a crucial role in sustaining chronic inflammation in...

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Detalles Bibliográficos
Autores principales: Milia, Anna Franca, Ibba-Manneschi, Lidia, Manetti, Mirko, Benelli, Gemma, Generini, Sergio, Messerini, Luca, Matucci-Cerinic, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822794/
https://www.ncbi.nlm.nih.gov/pubmed/20015205
http://dx.doi.org/10.1111/j.1582-4934.2009.00984.x