NK cells engineered to express a GD(2)-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin

Treatment of high-risk neuroblastoma (NB) represents a major challenge in paediatric oncology. Alternative therapeutic strategies include antibodies targeting the disialoganglioside GD(2), which is expressed at high levels on NB cells, and infusion of donor-derived natural killer (NK) cells. To comb...

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Detalles Bibliográficos
Autores principales: Esser, Ruth, Müller, Tina, Stefes, Dörthe, Kloess, Stephan, Seidel, Diana, Gillies, Stephen D, Aperlo-Iffland, Christel, Huston, James S, Uherek, Christoph, Schönfeld, Kurt, Tonn, Torsten, Huebener, Nicole, Lode, Holger N, Koehl, Ulrike, Wels, Winfried S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822932/
https://www.ncbi.nlm.nih.gov/pubmed/21595822
http://dx.doi.org/10.1111/j.1582-4934.2011.01343.x

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