Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation

We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene...

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Detalles Bibliográficos
Autores principales: Mahmood, Meena, Li, Zhiguang, Casciano, Daniel, Khodakovskaya, Mariya V, Chen, Tao, Karmakar, Alokita, Dervishi, Enkeleda, Xu, Yang, Mustafa, Thikra, Watanabe, Fumiya, Fejleh, Ashley, Whitlow, Morgan, Al-Adami, Mustafa, Ghosh, Anindya, Biris, Alexandru S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822941/
https://www.ncbi.nlm.nih.gov/pubmed/21143388
http://dx.doi.org/10.1111/j.1582-4934.2010.01234.x
Descripción
Sumario:We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.

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