Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation

We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene...

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Autores principales: Mahmood, Meena, Li, Zhiguang, Casciano, Daniel, Khodakovskaya, Mariya V, Chen, Tao, Karmakar, Alokita, Dervishi, Enkeleda, Xu, Yang, Mustafa, Thikra, Watanabe, Fumiya, Fejleh, Ashley, Whitlow, Morgan, Al-Adami, Mustafa, Ghosh, Anindya, Biris, Alexandru S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822941/
https://www.ncbi.nlm.nih.gov/pubmed/21143388
http://dx.doi.org/10.1111/j.1582-4934.2010.01234.x
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author Mahmood, Meena
Li, Zhiguang
Casciano, Daniel
Khodakovskaya, Mariya V
Chen, Tao
Karmakar, Alokita
Dervishi, Enkeleda
Xu, Yang
Mustafa, Thikra
Watanabe, Fumiya
Fejleh, Ashley
Whitlow, Morgan
Al-Adami, Mustafa
Ghosh, Anindya
Biris, Alexandru S
author_facet Mahmood, Meena
Li, Zhiguang
Casciano, Daniel
Khodakovskaya, Mariya V
Chen, Tao
Karmakar, Alokita
Dervishi, Enkeleda
Xu, Yang
Mustafa, Thikra
Watanabe, Fumiya
Fejleh, Ashley
Whitlow, Morgan
Al-Adami, Mustafa
Ghosh, Anindya
Biris, Alexandru S
author_sort Mahmood, Meena
collection PubMed
description We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.
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spelling pubmed-38229412015-04-06 Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation Mahmood, Meena Li, Zhiguang Casciano, Daniel Khodakovskaya, Mariya V Chen, Tao Karmakar, Alokita Dervishi, Enkeleda Xu, Yang Mustafa, Thikra Watanabe, Fumiya Fejleh, Ashley Whitlow, Morgan Al-Adami, Mustafa Ghosh, Anindya Biris, Alexandru S J Cell Mol Med Original Articles We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs. Blackwell Publishing Ltd 2011-11 2011-10-24 /pmc/articles/PMC3822941/ /pubmed/21143388 http://dx.doi.org/10.1111/j.1582-4934.2010.01234.x Text en © 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Original Articles
Mahmood, Meena
Li, Zhiguang
Casciano, Daniel
Khodakovskaya, Mariya V
Chen, Tao
Karmakar, Alokita
Dervishi, Enkeleda
Xu, Yang
Mustafa, Thikra
Watanabe, Fumiya
Fejleh, Ashley
Whitlow, Morgan
Al-Adami, Mustafa
Ghosh, Anindya
Biris, Alexandru S
Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title_full Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title_fullStr Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title_full_unstemmed Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title_short Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation
title_sort nanostructural materials increase mineralization in bone cells and affect gene expression through mirna regulation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822941/
https://www.ncbi.nlm.nih.gov/pubmed/21143388
http://dx.doi.org/10.1111/j.1582-4934.2010.01234.x
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