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Histamine: an undercover agent in multiple rare diseases?
Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. It is the product of the histidine decarboxylase activity, and its effects are mainly medi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822965/ https://www.ncbi.nlm.nih.gov/pubmed/22435405 http://dx.doi.org/10.1111/j.1582-4934.2012.01566.x |
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author | Pino-Ángeles, Almudena Reyes-Palomares, Armando Melgarejo, Esther Sánchez-Jiménez, Francisca |
author_facet | Pino-Ángeles, Almudena Reyes-Palomares, Armando Melgarejo, Esther Sánchez-Jiménez, Francisca |
author_sort | Pino-Ángeles, Almudena |
collection | PubMed |
description | Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. It is the product of the histidine decarboxylase activity, and its effects are mainly mediated through four different G-protein coupled receptors. Thus, histamine-related effects are the results of highly interconnected and tissue-specific signalling networks. Consequently, alterations in histamine-related factors could be an important part in the cause of multiple rare/orphan diseases. Bearing this hypothesis in mind, more than 25 rare diseases related to histamine physiopathology have been identified using a computationally assisted text mining approach. These newly integrated data will provide insight to elucidate the molecular causes of these rare diseases. The data can also help in devising new intervention strategies for personalized medicine for multiple rare diseases. |
format | Online Article Text |
id | pubmed-3822965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38229652015-03-27 Histamine: an undercover agent in multiple rare diseases? Pino-Ángeles, Almudena Reyes-Palomares, Armando Melgarejo, Esther Sánchez-Jiménez, Francisca J Cell Mol Med Reviews Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. It is the product of the histidine decarboxylase activity, and its effects are mainly mediated through four different G-protein coupled receptors. Thus, histamine-related effects are the results of highly interconnected and tissue-specific signalling networks. Consequently, alterations in histamine-related factors could be an important part in the cause of multiple rare/orphan diseases. Bearing this hypothesis in mind, more than 25 rare diseases related to histamine physiopathology have been identified using a computationally assisted text mining approach. These newly integrated data will provide insight to elucidate the molecular causes of these rare diseases. The data can also help in devising new intervention strategies for personalized medicine for multiple rare diseases. Blackwell Publishing Ltd 2012-09 2012-08-23 /pmc/articles/PMC3822965/ /pubmed/22435405 http://dx.doi.org/10.1111/j.1582-4934.2012.01566.x Text en Copyright © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. |
spellingShingle | Reviews Pino-Ángeles, Almudena Reyes-Palomares, Armando Melgarejo, Esther Sánchez-Jiménez, Francisca Histamine: an undercover agent in multiple rare diseases? |
title | Histamine: an undercover agent in multiple rare diseases? |
title_full | Histamine: an undercover agent in multiple rare diseases? |
title_fullStr | Histamine: an undercover agent in multiple rare diseases? |
title_full_unstemmed | Histamine: an undercover agent in multiple rare diseases? |
title_short | Histamine: an undercover agent in multiple rare diseases? |
title_sort | histamine: an undercover agent in multiple rare diseases? |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822965/ https://www.ncbi.nlm.nih.gov/pubmed/22435405 http://dx.doi.org/10.1111/j.1582-4934.2012.01566.x |
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