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The embryonic epicardium: an essential element of cardiac development

The epicardium has recently been identified as an active and essential element of cardiac development. Recent reports have unveiled a variety of functions performed by the embryonic epicardium, as well as the cellular and molecular mechanisms regulating them. However, despite its developmental impor...

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Autores principales: Carmona, R, Guadix, J A, Cano, E, Ruiz-Villalba, A, Portillo-Sánchez, V, Pérez-Pomares, J M, Muñoz-Chápuli, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822997/
https://www.ncbi.nlm.nih.gov/pubmed/20477903
http://dx.doi.org/10.1111/j.1582-4934.2010.01088.x
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author Carmona, R
Guadix, J A
Cano, E
Ruiz-Villalba, A
Portillo-Sánchez, V
Pérez-Pomares, J M
Muñoz-Chápuli, R
author_facet Carmona, R
Guadix, J A
Cano, E
Ruiz-Villalba, A
Portillo-Sánchez, V
Pérez-Pomares, J M
Muñoz-Chápuli, R
author_sort Carmona, R
collection PubMed
description The epicardium has recently been identified as an active and essential element of cardiac development. Recent reports have unveiled a variety of functions performed by the embryonic epicardium, as well as the cellular and molecular mechanisms regulating them. However, despite its developmental importance, a number of unsolved issues related to embryonic epicardial biology persist. In this review, we will summarize our current knowledge about (i) the ontogeny and evolution of the epicardium, including a discussion on the evolutionary origins of the proepicardium (the epicardial primordium), (ii) the nature of epicardial–myocardial interactions during development, known to be essential for myocardial growth and maturation, and (iii) the contribution of epicardially derived cells to the vascular and connective tissue of the heart. We will finish with a note on the relationships existing between the primordia of the viscera and their coelomic epithelial lining. We would like to suggest that at least a part of the properties of the embryonic epicardium are shared by many other coelomic cell types, such that the role of epicardium in cardiac development is a particular example of a more general mechanism for the contribution of coelomic and coelomic-derived cells to the morphogenesis of organs such as the liver, kidneys, gonads or spleen.
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spelling pubmed-38229972015-04-20 The embryonic epicardium: an essential element of cardiac development Carmona, R Guadix, J A Cano, E Ruiz-Villalba, A Portillo-Sánchez, V Pérez-Pomares, J M Muñoz-Chápuli, R J Cell Mol Med Reviews The epicardium has recently been identified as an active and essential element of cardiac development. Recent reports have unveiled a variety of functions performed by the embryonic epicardium, as well as the cellular and molecular mechanisms regulating them. However, despite its developmental importance, a number of unsolved issues related to embryonic epicardial biology persist. In this review, we will summarize our current knowledge about (i) the ontogeny and evolution of the epicardium, including a discussion on the evolutionary origins of the proepicardium (the epicardial primordium), (ii) the nature of epicardial–myocardial interactions during development, known to be essential for myocardial growth and maturation, and (iii) the contribution of epicardially derived cells to the vascular and connective tissue of the heart. We will finish with a note on the relationships existing between the primordia of the viscera and their coelomic epithelial lining. We would like to suggest that at least a part of the properties of the embryonic epicardium are shared by many other coelomic cell types, such that the role of epicardium in cardiac development is a particular example of a more general mechanism for the contribution of coelomic and coelomic-derived cells to the morphogenesis of organs such as the liver, kidneys, gonads or spleen. Blackwell Publishing Ltd 2010-08 2010-05-14 /pmc/articles/PMC3822997/ /pubmed/20477903 http://dx.doi.org/10.1111/j.1582-4934.2010.01088.x Text en © 2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Carmona, R
Guadix, J A
Cano, E
Ruiz-Villalba, A
Portillo-Sánchez, V
Pérez-Pomares, J M
Muñoz-Chápuli, R
The embryonic epicardium: an essential element of cardiac development
title The embryonic epicardium: an essential element of cardiac development
title_full The embryonic epicardium: an essential element of cardiac development
title_fullStr The embryonic epicardium: an essential element of cardiac development
title_full_unstemmed The embryonic epicardium: an essential element of cardiac development
title_short The embryonic epicardium: an essential element of cardiac development
title_sort embryonic epicardium: an essential element of cardiac development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822997/
https://www.ncbi.nlm.nih.gov/pubmed/20477903
http://dx.doi.org/10.1111/j.1582-4934.2010.01088.x
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