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Advances in microRNAs: implications for immunity and inflammatory diseases
Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823034/ https://www.ncbi.nlm.nih.gov/pubmed/19175698 http://dx.doi.org/10.1111/j.1582-4934.2008.00534.x |
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author | Sonkoly, E Pivarcsi, A |
author_facet | Sonkoly, E Pivarcsi, A |
author_sort | Sonkoly, E |
collection | PubMed |
description | Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections. |
format | Online Article Text |
id | pubmed-3823034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38230342015-04-27 Advances in microRNAs: implications for immunity and inflammatory diseases Sonkoly, E Pivarcsi, A J Cell Mol Med Reviews Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections. Blackwell Publishing Ltd 2009-01 2008-10-13 /pmc/articles/PMC3823034/ /pubmed/19175698 http://dx.doi.org/10.1111/j.1582-4934.2008.00534.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Sonkoly, E Pivarcsi, A Advances in microRNAs: implications for immunity and inflammatory diseases |
title | Advances in microRNAs: implications for immunity and inflammatory diseases |
title_full | Advances in microRNAs: implications for immunity and inflammatory diseases |
title_fullStr | Advances in microRNAs: implications for immunity and inflammatory diseases |
title_full_unstemmed | Advances in microRNAs: implications for immunity and inflammatory diseases |
title_short | Advances in microRNAs: implications for immunity and inflammatory diseases |
title_sort | advances in micrornas: implications for immunity and inflammatory diseases |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823034/ https://www.ncbi.nlm.nih.gov/pubmed/19175698 http://dx.doi.org/10.1111/j.1582-4934.2008.00534.x |
work_keys_str_mv | AT sonkolye advancesinmicrornasimplicationsforimmunityandinflammatorydiseases AT pivarcsia advancesinmicrornasimplicationsforimmunityandinflammatorydiseases |