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Endothelial progenitor cells: identity defined?

In the past decade, researchers have gained important insights on the role of bone marrow (BM)-derived cells in adult neovascularization. A subset of BM-derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neova...

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Autores principales: Timmermans, Frank, Plum, Jean, Yöder, Mervin C, Ingram, David A, Vandekerckhove, Bart, Case, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823038/
https://www.ncbi.nlm.nih.gov/pubmed/19067770
http://dx.doi.org/10.1111/j.1582-4934.2008.00598.x
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author Timmermans, Frank
Plum, Jean
Yöder, Mervin C
Ingram, David A
Vandekerckhove, Bart
Case, Jamie
author_facet Timmermans, Frank
Plum, Jean
Yöder, Mervin C
Ingram, David A
Vandekerckhove, Bart
Case, Jamie
author_sort Timmermans, Frank
collection PubMed
description In the past decade, researchers have gained important insights on the role of bone marrow (BM)-derived cells in adult neovascularization. A subset of BM-derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis. Therefore, EPCs were proposed as a potential regenerative tool for treating human vascular disease and a possible target to restrict vessel growth in tumour pathology. However, conflicting results have been reported in the field, and the identification, characterization, and exact role of EPCs in vascular biology is still a subject of much discussion. The focus of this review is on the controversial issues in the field of EPCs which are related to the lack of a unique EPC marker, identification challenges related to the paucity of EPCs in the circulation, and the important phenotypical and functional overlap between EPCs, haematopoietic cells and mature ECs. We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133(+) cells or CD45(+) haematopoietic cells.
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spelling pubmed-38230382015-04-27 Endothelial progenitor cells: identity defined? Timmermans, Frank Plum, Jean Yöder, Mervin C Ingram, David A Vandekerckhove, Bart Case, Jamie J Cell Mol Med Reviews In the past decade, researchers have gained important insights on the role of bone marrow (BM)-derived cells in adult neovascularization. A subset of BM-derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis. Therefore, EPCs were proposed as a potential regenerative tool for treating human vascular disease and a possible target to restrict vessel growth in tumour pathology. However, conflicting results have been reported in the field, and the identification, characterization, and exact role of EPCs in vascular biology is still a subject of much discussion. The focus of this review is on the controversial issues in the field of EPCs which are related to the lack of a unique EPC marker, identification challenges related to the paucity of EPCs in the circulation, and the important phenotypical and functional overlap between EPCs, haematopoietic cells and mature ECs. We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133(+) cells or CD45(+) haematopoietic cells. Blackwell Publishing Ltd 2009-01 2008-12-03 /pmc/articles/PMC3823038/ /pubmed/19067770 http://dx.doi.org/10.1111/j.1582-4934.2008.00598.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Timmermans, Frank
Plum, Jean
Yöder, Mervin C
Ingram, David A
Vandekerckhove, Bart
Case, Jamie
Endothelial progenitor cells: identity defined?
title Endothelial progenitor cells: identity defined?
title_full Endothelial progenitor cells: identity defined?
title_fullStr Endothelial progenitor cells: identity defined?
title_full_unstemmed Endothelial progenitor cells: identity defined?
title_short Endothelial progenitor cells: identity defined?
title_sort endothelial progenitor cells: identity defined?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823038/
https://www.ncbi.nlm.nih.gov/pubmed/19067770
http://dx.doi.org/10.1111/j.1582-4934.2008.00598.x
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