Cargando…
Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example,...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823047/ https://www.ncbi.nlm.nih.gov/pubmed/19175701 http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x |
_version_ | 1782290501645369344 |
---|---|
author | Gherghiceanu, M Hinescu, M E Popescu, L M |
author_facet | Gherghiceanu, M Hinescu, M E Popescu, L M |
author_sort | Gherghiceanu, M |
collection | PubMed |
description | We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example, location among cardiomyocytes, close vicinity to nerves and/or blood capillaries, specialized cell-to-cell junctions, presence of 2–3 typical processes, which are very long (several tens of micrometres), but are very thin (0.1–0.2 μm) and moniliform. However, the most striking modification of myocardial ICLC in caveolin-1 KO mice was the absence of caveolae. Beyond this main observation, three other findings could be reported: (1) the absence of caveolae in capillary endothelium, (2) persistence of (some) caveolae at the level of cardiomyocte sarcolemma or vascular smooth muscle cell sarcolemma and (3) (un)expected ultrastructural modifications such as increased thickness of capillary basement membrane and increased autophagy of several cardiomyocytes. |
format | Online Article Text |
id | pubmed-3823047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38230472015-04-27 Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice Gherghiceanu, M Hinescu, M E Popescu, L M J Cell Mol Med Articles We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example, location among cardiomyocytes, close vicinity to nerves and/or blood capillaries, specialized cell-to-cell junctions, presence of 2–3 typical processes, which are very long (several tens of micrometres), but are very thin (0.1–0.2 μm) and moniliform. However, the most striking modification of myocardial ICLC in caveolin-1 KO mice was the absence of caveolae. Beyond this main observation, three other findings could be reported: (1) the absence of caveolae in capillary endothelium, (2) persistence of (some) caveolae at the level of cardiomyocte sarcolemma or vascular smooth muscle cell sarcolemma and (3) (un)expected ultrastructural modifications such as increased thickness of capillary basement membrane and increased autophagy of several cardiomyocytes. Blackwell Publishing Ltd 2009-01 2009-01-21 /pmc/articles/PMC3823047/ /pubmed/19175701 http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Articles Gherghiceanu, M Hinescu, M E Popescu, L M Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title | Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title_full | Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title_fullStr | Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title_full_unstemmed | Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title_short | Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice |
title_sort | myocardial interstitial cajal-like cells (iclc) in caveolin-1 ko mice |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823047/ https://www.ncbi.nlm.nih.gov/pubmed/19175701 http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x |
work_keys_str_mv | AT gherghiceanum myocardialinterstitialcajallikecellsiclcincaveolin1komice AT hinescume myocardialinterstitialcajallikecellsiclcincaveolin1komice AT popesculm myocardialinterstitialcajallikecellsiclcincaveolin1komice |