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Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice

We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example,...

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Detalles Bibliográficos
Autores principales: Gherghiceanu, M, Hinescu, M E, Popescu, L M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823047/
https://www.ncbi.nlm.nih.gov/pubmed/19175701
http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x
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author Gherghiceanu, M
Hinescu, M E
Popescu, L M
author_facet Gherghiceanu, M
Hinescu, M E
Popescu, L M
author_sort Gherghiceanu, M
collection PubMed
description We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example, location among cardiomyocytes, close vicinity to nerves and/or blood capillaries, specialized cell-to-cell junctions, presence of 2–3 typical processes, which are very long (several tens of micrometres), but are very thin (0.1–0.2 μm) and moniliform. However, the most striking modification of myocardial ICLC in caveolin-1 KO mice was the absence of caveolae. Beyond this main observation, three other findings could be reported: (1) the absence of caveolae in capillary endothelium, (2) persistence of (some) caveolae at the level of cardiomyocte sarcolemma or vascular smooth muscle cell sarcolemma and (3) (un)expected ultrastructural modifications such as increased thickness of capillary basement membrane and increased autophagy of several cardiomyocytes.
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spelling pubmed-38230472015-04-27 Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice Gherghiceanu, M Hinescu, M E Popescu, L M J Cell Mol Med Articles We compared, by transmission electron microscopy (TEM), the ultrastructure of interstitial Cajal-like cells (ICLC) in normal mammalian myocardium versus caveolin-1 null mice. TEM showed that myocardial ICLCs of caveolin-1-deficient mice retain their main ultrastructural characteristics, for example, location among cardiomyocytes, close vicinity to nerves and/or blood capillaries, specialized cell-to-cell junctions, presence of 2–3 typical processes, which are very long (several tens of micrometres), but are very thin (0.1–0.2 μm) and moniliform. However, the most striking modification of myocardial ICLC in caveolin-1 KO mice was the absence of caveolae. Beyond this main observation, three other findings could be reported: (1) the absence of caveolae in capillary endothelium, (2) persistence of (some) caveolae at the level of cardiomyocte sarcolemma or vascular smooth muscle cell sarcolemma and (3) (un)expected ultrastructural modifications such as increased thickness of capillary basement membrane and increased autophagy of several cardiomyocytes. Blackwell Publishing Ltd 2009-01 2009-01-21 /pmc/articles/PMC3823047/ /pubmed/19175701 http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Articles
Gherghiceanu, M
Hinescu, M E
Popescu, L M
Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title_full Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title_fullStr Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title_full_unstemmed Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title_short Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
title_sort myocardial interstitial cajal-like cells (iclc) in caveolin-1 ko mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823047/
https://www.ncbi.nlm.nih.gov/pubmed/19175701
http://dx.doi.org/10.1111/j.1582-4934.2008.00615.x
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