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The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis
OBJECTIVE: To investigate the response of patients with peripheral neuropathic pain (PNP) to capsaicin 8% patch treatment in a clinical setting. DESIGN: Retrospective analysis. SETTING: The Clinic for Pain Therapy and Palliative Medicine at the Medical Centre for the region of Aachen, Germany. SUBJE...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823063/ https://www.ncbi.nlm.nih.gov/pubmed/23710678 http://dx.doi.org/10.1111/pme.12143 |
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author | Wagner, Till Poole, Chris Roth-Daniek, Andrea |
author_facet | Wagner, Till Poole, Chris Roth-Daniek, Andrea |
author_sort | Wagner, Till |
collection | PubMed |
description | OBJECTIVE: To investigate the response of patients with peripheral neuropathic pain (PNP) to capsaicin 8% patch treatment in a clinical setting. DESIGN: Retrospective analysis. SETTING: The Clinic for Pain Therapy and Palliative Medicine at the Medical Centre for the region of Aachen, Germany. SUBJECTS: Patients diagnosed with PNP who attended the clinic for capsaicin 8% patch treatment between January 13, 2010 and February 7, 2011. OUTCOME MEASURES: Pain intensity was assessed using the Numeric Pain Rating Scale (NPRS) at baseline and following each capsaicin 8% patch treatment. Changes in prescribed concomitant neuropathic pain (NP) medications and response duration were recorded. RESULTS: Overall, 68 patients with PNP conditions, including facial neuropathy (severe trigeminal neuralgia in V2), polyneuropathy, post-herpetic neuralgia, and mononeuropathies, received 96 treatments with the capsaicin 8% patch. The 53 patients with a follow-up of ≥8 weeks demonstrated a 48.4% mean reduction in NPRS score from baseline to Weeks 1–8. Among the 37 responders (those exhibiting ≥30% reduction in NPRS score from baseline to Weeks 1–8), the median time to re-treatment was 125 days. Following treatment, there was a significant (P < 0.001) 54% reduction in the mean number of prescribed concomitant NP medications taken by patients. CONCLUSIONS: This analysis demonstrates that in clinical practice, the capsaicin 8% patch provides rapid and sustained pain reductions in patients with a variety of PNP conditions and a significant reduction in prescribed concomitant NP medications. The capsaicin 8% patch can be a valuable addition to the NP treatment armory for certain patients. |
format | Online Article Text |
id | pubmed-3823063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38230632013-12-03 The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis Wagner, Till Poole, Chris Roth-Daniek, Andrea Pain Med Neuropathic Pain Section OBJECTIVE: To investigate the response of patients with peripheral neuropathic pain (PNP) to capsaicin 8% patch treatment in a clinical setting. DESIGN: Retrospective analysis. SETTING: The Clinic for Pain Therapy and Palliative Medicine at the Medical Centre for the region of Aachen, Germany. SUBJECTS: Patients diagnosed with PNP who attended the clinic for capsaicin 8% patch treatment between January 13, 2010 and February 7, 2011. OUTCOME MEASURES: Pain intensity was assessed using the Numeric Pain Rating Scale (NPRS) at baseline and following each capsaicin 8% patch treatment. Changes in prescribed concomitant neuropathic pain (NP) medications and response duration were recorded. RESULTS: Overall, 68 patients with PNP conditions, including facial neuropathy (severe trigeminal neuralgia in V2), polyneuropathy, post-herpetic neuralgia, and mononeuropathies, received 96 treatments with the capsaicin 8% patch. The 53 patients with a follow-up of ≥8 weeks demonstrated a 48.4% mean reduction in NPRS score from baseline to Weeks 1–8. Among the 37 responders (those exhibiting ≥30% reduction in NPRS score from baseline to Weeks 1–8), the median time to re-treatment was 125 days. Following treatment, there was a significant (P < 0.001) 54% reduction in the mean number of prescribed concomitant NP medications taken by patients. CONCLUSIONS: This analysis demonstrates that in clinical practice, the capsaicin 8% patch provides rapid and sustained pain reductions in patients with a variety of PNP conditions and a significant reduction in prescribed concomitant NP medications. The capsaicin 8% patch can be a valuable addition to the NP treatment armory for certain patients. Blackwell Publishing Ltd 2013-08 2013-05-24 /pmc/articles/PMC3823063/ /pubmed/23710678 http://dx.doi.org/10.1111/pme.12143 Text en © 2013 American Academy of Pain Medicine http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Neuropathic Pain Section Wagner, Till Poole, Chris Roth-Daniek, Andrea The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title | The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title_full | The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title_fullStr | The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title_full_unstemmed | The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title_short | The Capsaicin 8% Patch for Neuropathic Pain in Clinical Practice: A Retrospective Analysis |
title_sort | capsaicin 8% patch for neuropathic pain in clinical practice: a retrospective analysis |
topic | Neuropathic Pain Section |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823063/ https://www.ncbi.nlm.nih.gov/pubmed/23710678 http://dx.doi.org/10.1111/pme.12143 |
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