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Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

According to epidemiological studies, type-2 diabetes increases the risk of Alzheimer’s disease. Here, we induced hyperglycaemia in mice overexpressing mutant amyloid precursor protein and presenilin-1 (APdE9) either by cross-breeding them with pancreatic insulin-like growth factor 2 (IGF-2) overexp...

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Detalles Bibliográficos
Autores principales:	Hiltunen, Mikko, Khandelwal, Vinoth K M, Yaluri, Nagendra, Tiilikainen, Tea, Tusa, Maija, Koivisto, Henna, Krzisch, Marine, Vepsäläinen, Saila, Mäkinen, Petra, Kemppainen, Susanna, Miettinen, Pasi, Haapasalo, Annakaisa, Soininen, Hilkka, Laakso, Markku, Tanila, Heikki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823075/ https://www.ncbi.nlm.nih.gov/pubmed/21762376 http://dx.doi.org/10.1111/j.1582-4934.2011.01384.x

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