Cargando…

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

Among the multitude of dysregulated signalling mechanisms that comprise insulin resistance in divergent organs, the primary events in the development of type 2 diabetes are not well established. As protein kinase C (PKC) activation is consistently present in skeletal muscle of obese and insulin resi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hennige, Anita M, Heni, Martin, Machann, Jürgen, Staiger, Harald, Sartorius, Tina, Hoene, Miriam, Lehmann, Rainer, Weigert, Cora, Peter, Andreas, Bornemann, Antje, Kroeber, Stefan, Pujol, Anna, Franckhauser, Sylvie, Bosch, Fatima, Schick, Fritz, Lammers, Reiner, Häring, Hans-Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823122/ https://www.ncbi.nlm.nih.gov/pubmed/20569275 http://dx.doi.org/10.1111/j.1582-4934.2008.00629.x

Ejemplares similares

Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity
por: Sartorius, Tina, et al.
Publicado: (2014)

Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo
por: Peter, Andreas, et al.
Publicado: (2009)

Medium Chain Acylcarnitines Dominate the Metabolite Pattern in Humans under Moderate Intensity Exercise and Support Lipid Oxidation
por: Lehmann, Rainer, et al.
Publicado: (2010)

Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans
por: Hoene, Miriam, et al.
Publicado: (2022)

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers
por: Kächele, Martin, et al.
Publicado: (2015)

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity
por: Staiger, Harald, et al.
Publicado: (2013)

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
por: Böhm, Anja, et al.
Publicado: (2012)

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples
por: Kappler, Lisa, et al.
Publicado: (2016)

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
por: Haupt, Axel, et al.
Publicado: (2010)

Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
por: Hummel, Julia, et al.
Publicado: (2021)

Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior
por: Sartorius, Tina, et al.
Publicado: (2012)

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content
por: Machicao, Fausto, et al.
Publicado: (2016)

The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?
por: Sartorius, Tina, et al.
Publicado: (2015)

Exercise and diabetes: relevance and causes for response variability
por: Böhm, Anja, et al.
Publicado: (2015)

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
por: Müssig, Karsten, et al.
Publicado: (2010)

Common Genetic Variation in the Human CTF1 Locus, Encoding Cardiotrophin-1, Determines Insulin Sensitivity
por: Lutz, Stefan Z., et al.
Publicado: (2014)

Lipidomics Analysis Reveals Efficient Storage of Hepatic Triacylglycerides Enriched in Unsaturated Fatty Acids after One Bout of Exercise in Mice
por: Hu, Chunxiu, et al.
Publicado: (2010)

Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice
por: Hoene, Miriam, et al.
Publicado: (2016)

Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
por: Kullmann, Stephanie, et al.
Publicado: (2022)

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia
por: Lutz, Stefan Z., et al.
Publicado: (2011)

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
por: Staiger, Harald, et al.
Publicado: (2009)

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
por: Peter, Andreas, et al.
Publicado: (2010)

Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
por: Maurer, Jennifer, et al.
Publicado: (2021)

A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice
por: Hoene, Miriam, et al.
Publicado: (2018)

The Acute Cytokine Response to 30-Minute Exercise Bouts Before and After 8-Week Endurance Training in Individuals With Obesity
por: Goj, Thomas, et al.
Publicado: (2022)

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans
por: Stefan, Norbert, et al.
Publicado: (2010)

Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion
por: Sartorius, Tina, et al.
Publicado: (2016)

The D299G/T399I Toll-Like Receptor 4 Variant Associates with Body and Liver Fat: Results from the TULIP and METSIM Studies
por: Weyrich, Peter, et al.
Publicado: (2010)

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans
por: Lutz, Stefan Z., et al.
Publicado: (2018)

Lack of Gα(i2) proteins in adipocytes attenuates diet-induced obesity
por: Leiss, Veronika, et al.
Publicado: (2020)

Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes
por: Heni, Martin, et al.
Publicado: (2011)

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
por: Randrianarisoa, Elko, et al.
Publicado: (2016)

New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance
por: Elias, Ivet, et al.
Publicado: (2013)

Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813
por: Elias, Ivet, et al.
Publicado: (2013)

Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism
por: Hu, Chunxiu, et al.
Publicado: (2019)

A comparison of emulsifiers for the formation of oil-in-water emulsions: stability of the emulsions within 9 h after production and MR signal properties
por: Fritz, Victor, et al.
Publicado: (2021)

Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
por: Hennige, Anita M., et al.
Publicado: (2008)

Cholesterol Synthesis Is Associated with Hepatic Lipid Content and Dependent on Fructose/Glucose Intake in Healthy Humans
por: Silbernagel, Guenther, et al.
Publicado: (2012)

SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study
por: Weyrich, Peter, et al.
Publicado: (2008)

Reduced cortical thickness associated with visceral fat and BMI
por: Veit, Ralf, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4iab06n175bdsputvq7tdb915r