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Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta
Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation in embryo. Despite surgical repair of the defect, most of the patients who survive with NTDs have a multiple system handicap due to neuron deficiency of the defective spinal cord. In this study, we...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823228/ https://www.ncbi.nlm.nih.gov/pubmed/22004004 http://dx.doi.org/10.1111/j.1582-4934.2011.01470.x |
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author | Li, Hui Gao, Fei Ma, Lili Jiang, Junhong Miao, Jianing Jiang, Mingyu Fan, Yang Wang, Lili Wu, Di Liu, Bo Wang, Weilin Lui, Vincent Chi Hang Yuan, Zhengwei |
author_facet | Li, Hui Gao, Fei Ma, Lili Jiang, Junhong Miao, Jianing Jiang, Mingyu Fan, Yang Wang, Lili Wu, Di Liu, Bo Wang, Weilin Lui, Vincent Chi Hang Yuan, Zhengwei |
author_sort | Li, Hui |
collection | PubMed |
description | Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation in embryo. Despite surgical repair of the defect, most of the patients who survive with NTDs have a multiple system handicap due to neuron deficiency of the defective spinal cord. In this study, we successfully devised a prenatal surgical approach and transplanted mesenchymal stem cells (MSCs) to foetal rat spinal column to treat retinoic acid induced NTDs in rat. Transplanted MSCs survived, grew and expressed markers of neurons, glia and myoblasts in the defective spinal cord. MSCs expressed and perhaps induced the surrounding spinal tissue to express neurotrophic factors. In addition, MSC reduced spinal tissue apoptosis in NTD. Our results suggested that prenatal MSC transplantation could treat spinal neuron deficiency in NTDs by the regeneration of neurons and reduced spinal neuron death in the defective spinal cord. |
format | Online Article Text |
id | pubmed-3823228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38232282015-03-27 Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta Li, Hui Gao, Fei Ma, Lili Jiang, Junhong Miao, Jianing Jiang, Mingyu Fan, Yang Wang, Lili Wu, Di Liu, Bo Wang, Weilin Lui, Vincent Chi Hang Yuan, Zhengwei J Cell Mol Med Original Articles Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation in embryo. Despite surgical repair of the defect, most of the patients who survive with NTDs have a multiple system handicap due to neuron deficiency of the defective spinal cord. In this study, we successfully devised a prenatal surgical approach and transplanted mesenchymal stem cells (MSCs) to foetal rat spinal column to treat retinoic acid induced NTDs in rat. Transplanted MSCs survived, grew and expressed markers of neurons, glia and myoblasts in the defective spinal cord. MSCs expressed and perhaps induced the surrounding spinal tissue to express neurotrophic factors. In addition, MSC reduced spinal tissue apoptosis in NTD. Our results suggested that prenatal MSC transplantation could treat spinal neuron deficiency in NTDs by the regeneration of neurons and reduced spinal neuron death in the defective spinal cord. Blackwell Publishing Ltd 2012-07 2012-06-28 /pmc/articles/PMC3823228/ /pubmed/22004004 http://dx.doi.org/10.1111/j.1582-4934.2011.01470.x Text en Copyright © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. |
spellingShingle | Original Articles Li, Hui Gao, Fei Ma, Lili Jiang, Junhong Miao, Jianing Jiang, Mingyu Fan, Yang Wang, Lili Wu, Di Liu, Bo Wang, Weilin Lui, Vincent Chi Hang Yuan, Zhengwei Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title | Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title_full | Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title_fullStr | Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title_full_unstemmed | Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title_short | Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta |
title_sort | therapeutic potential of in utero mesenchymal stem cell (mscs) transplantation in rat foetuses with spina bifida aperta |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823228/ https://www.ncbi.nlm.nih.gov/pubmed/22004004 http://dx.doi.org/10.1111/j.1582-4934.2011.01470.x |
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