Cargando…
Role of the soluble pattern recognition receptor PTX3 in vascular biology
Pentraxins act as soluble pattern recognition receptors with a wide range of functions in various pathophysiological conditions. The long-pentraxin PTX3 shares the C-terminal pentraxin-domain with short-pentraxins C-reactive protein and serum amyloid P component and possesses an unique N-terminal do...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823252/ https://www.ncbi.nlm.nih.gov/pubmed/17760835 http://dx.doi.org/10.1111/j.1582-4934.2007.00061.x |
_version_ | 1782290538098065408 |
---|---|
author | Presta, Marco Camozzi, Maura Salvatori, Giovanni Rusnati, Marco |
author_facet | Presta, Marco Camozzi, Maura Salvatori, Giovanni Rusnati, Marco |
author_sort | Presta, Marco |
collection | PubMed |
description | Pentraxins act as soluble pattern recognition receptors with a wide range of functions in various pathophysiological conditions. The long-pentraxin PTX3 shares the C-terminal pentraxin-domain with short-pentraxins C-reactive protein and serum amyloid P component and possesses an unique N-terminal domain. These structural features suggest that PTX3 may have both overlapping and distinct biological/ligand recognition properties when compared to short-pentraxins. PTX3 serves as a mechanism of amplification of inflammation and innate immunity. Indeed, vessel wall elements produce high amounts of PTX3 during inflammation and the levels of circulating PTX3 increase in several pathological conditions affecting the cardiovascular system. PTX3 exists as a free or extracellular matrix-associated molecule and it binds the complement fraction C1q. PTX3 binds also apoptotic cells and selected pathogens, playing a role in innate immunity processes. In endothelial cells and macrophages, PTX3 upregulates tissue factor expression, suggesting its action as a regulator of endothelium during thrombogenesis and ischaemic vascular disease. Finally, PTX3 binds the angiogenic fibroblast growth factor-2, thus inhibiting its biological activity. Taken together, these properties point to a role for PTX3 during vascular damage, angiogenesis, atherosclerosis, and restenosis. |
format | Online Article Text |
id | pubmed-3823252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38232522015-04-27 Role of the soluble pattern recognition receptor PTX3 in vascular biology Presta, Marco Camozzi, Maura Salvatori, Giovanni Rusnati, Marco J Cell Mol Med Reviews Pentraxins act as soluble pattern recognition receptors with a wide range of functions in various pathophysiological conditions. The long-pentraxin PTX3 shares the C-terminal pentraxin-domain with short-pentraxins C-reactive protein and serum amyloid P component and possesses an unique N-terminal domain. These structural features suggest that PTX3 may have both overlapping and distinct biological/ligand recognition properties when compared to short-pentraxins. PTX3 serves as a mechanism of amplification of inflammation and innate immunity. Indeed, vessel wall elements produce high amounts of PTX3 during inflammation and the levels of circulating PTX3 increase in several pathological conditions affecting the cardiovascular system. PTX3 exists as a free or extracellular matrix-associated molecule and it binds the complement fraction C1q. PTX3 binds also apoptotic cells and selected pathogens, playing a role in innate immunity processes. In endothelial cells and macrophages, PTX3 upregulates tissue factor expression, suggesting its action as a regulator of endothelium during thrombogenesis and ischaemic vascular disease. Finally, PTX3 binds the angiogenic fibroblast growth factor-2, thus inhibiting its biological activity. Taken together, these properties point to a role for PTX3 during vascular damage, angiogenesis, atherosclerosis, and restenosis. Blackwell Publishing Ltd 2007-07 2007-06-14 /pmc/articles/PMC3823252/ /pubmed/17760835 http://dx.doi.org/10.1111/j.1582-4934.2007.00061.x Text en |
spellingShingle | Reviews Presta, Marco Camozzi, Maura Salvatori, Giovanni Rusnati, Marco Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title | Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title_full | Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title_fullStr | Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title_full_unstemmed | Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title_short | Role of the soluble pattern recognition receptor PTX3 in vascular biology |
title_sort | role of the soluble pattern recognition receptor ptx3 in vascular biology |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823252/ https://www.ncbi.nlm.nih.gov/pubmed/17760835 http://dx.doi.org/10.1111/j.1582-4934.2007.00061.x |
work_keys_str_mv | AT prestamarco roleofthesolublepatternrecognitionreceptorptx3invascularbiology AT camozzimaura roleofthesolublepatternrecognitionreceptorptx3invascularbiology AT salvatorigiovanni roleofthesolublepatternrecognitionreceptorptx3invascularbiology AT rusnatimarco roleofthesolublepatternrecognitionreceptorptx3invascularbiology |