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Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823261/ https://www.ncbi.nlm.nih.gov/pubmed/17760844 http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x |
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author | Sultana, Rukhsana Reed, Tanea Perluigi, Marzia Coccia, Rafaella Pierce, William M Butterfield, D Allan |
author_facet | Sultana, Rukhsana Reed, Tanea Perluigi, Marzia Coccia, Rafaella Pierce, William M Butterfield, D Allan |
author_sort | Sultana, Rukhsana |
collection | PubMed |
description | Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease. |
format | Online Article Text |
id | pubmed-3823261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38232612015-04-27 Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study Sultana, Rukhsana Reed, Tanea Perluigi, Marzia Coccia, Rafaella Pierce, William M Butterfield, D Allan J Cell Mol Med Articles Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease. Blackwell Publishing Ltd 2007-07 2007-06-24 /pmc/articles/PMC3823261/ /pubmed/17760844 http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x Text en |
spellingShingle | Articles Sultana, Rukhsana Reed, Tanea Perluigi, Marzia Coccia, Rafaella Pierce, William M Butterfield, D Allan Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title | Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title_full | Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title_fullStr | Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title_full_unstemmed | Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title_short | Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
title_sort | proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823261/ https://www.ncbi.nlm.nih.gov/pubmed/17760844 http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x |
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