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Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study

Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the...

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Detalles Bibliográficos
Autores principales: Sultana, Rukhsana, Reed, Tanea, Perluigi, Marzia, Coccia, Rafaella, Pierce, William M, Butterfield, D Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823261/
https://www.ncbi.nlm.nih.gov/pubmed/17760844
http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x
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author Sultana, Rukhsana
Reed, Tanea
Perluigi, Marzia
Coccia, Rafaella
Pierce, William M
Butterfield, D Allan
author_facet Sultana, Rukhsana
Reed, Tanea
Perluigi, Marzia
Coccia, Rafaella
Pierce, William M
Butterfield, D Allan
author_sort Sultana, Rukhsana
collection PubMed
description Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.
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spelling pubmed-38232612015-04-27 Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study Sultana, Rukhsana Reed, Tanea Perluigi, Marzia Coccia, Rafaella Pierce, William M Butterfield, D Allan J Cell Mol Med Articles Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease. Blackwell Publishing Ltd 2007-07 2007-06-24 /pmc/articles/PMC3823261/ /pubmed/17760844 http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x Text en
spellingShingle Articles
Sultana, Rukhsana
Reed, Tanea
Perluigi, Marzia
Coccia, Rafaella
Pierce, William M
Butterfield, D Allan
Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title_full Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title_fullStr Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title_full_unstemmed Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title_short Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
title_sort proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823261/
https://www.ncbi.nlm.nih.gov/pubmed/17760844
http://dx.doi.org/10.1111/j.1582-4934.2007.00065.x
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