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High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

Alzheimer’s disease (AD) is characterized by the aggregation and deposition of amyloid β protein (Aβ) in the brain. Soluble Aβ oligomers are thought to be toxic. To investigate the predominant species of Aβ protein that may play a role in AD pathogenesis, we performed biochemical analysis of AD and...

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Detalles Bibliográficos
Autores principales:	Upadhaya, Ajeet Rijal, Lungrin, Irina, Yamaguchi, Haruyasu, Fändrich, Marcus, Thal, Dietmar Rudolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823292/ https://www.ncbi.nlm.nih.gov/pubmed/21418518 http://dx.doi.org/10.1111/j.1582-4934.2011.01306.x

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