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Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma

Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in...

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Detalles Bibliográficos
Autores principales: Kreipke, Christian W, Rafols, Jose A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823353/
https://www.ncbi.nlm.nih.gov/pubmed/19278456
http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x
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author Kreipke, Christian W
Rafols, Jose A
author_facet Kreipke, Christian W
Rafols, Jose A
author_sort Kreipke, Christian W
collection PubMed
description Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI).
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spelling pubmed-38233532015-04-27 Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma Kreipke, Christian W Rafols, Jose A J Cell Mol Med Reviews Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI). Blackwell Publishing Ltd 2009-02 2008-10-03 /pmc/articles/PMC3823353/ /pubmed/19278456 http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
spellingShingle Reviews
Kreipke, Christian W
Rafols, Jose A
Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title_full Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title_fullStr Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title_full_unstemmed Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title_short Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
title_sort calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823353/
https://www.ncbi.nlm.nih.gov/pubmed/19278456
http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x
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