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Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma
Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823353/ https://www.ncbi.nlm.nih.gov/pubmed/19278456 http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x |
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author | Kreipke, Christian W Rafols, Jose A |
author_facet | Kreipke, Christian W Rafols, Jose A |
author_sort | Kreipke, Christian W |
collection | PubMed |
description | Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI). |
format | Online Article Text |
id | pubmed-3823353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38233532015-04-27 Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma Kreipke, Christian W Rafols, Jose A J Cell Mol Med Reviews Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI). Blackwell Publishing Ltd 2009-02 2008-10-03 /pmc/articles/PMC3823353/ /pubmed/19278456 http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x Text en © 2009 The Authors Journal compilation © 2009 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Kreipke, Christian W Rafols, Jose A Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title | Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title_full | Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title_fullStr | Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title_full_unstemmed | Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title_short | Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
title_sort | calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823353/ https://www.ncbi.nlm.nih.gov/pubmed/19278456 http://dx.doi.org/10.1111/j.1582-4934.2008.00508.x |
work_keys_str_mv | AT kreipkechristianw calponincontrolofcerebrovascularreactivitytherapeuticimplicationsinbraintrauma AT rafolsjosea calponincontrolofcerebrovascularreactivitytherapeuticimplicationsinbraintrauma |