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Reduced ligand affinity leads to an impaired function of the adenosine A(2A) receptor of human granulocytes in sepsis

The enhanced release of reactive oxygen species by excessively activated polymorphonuclear leucocytes (PMN) is a key step in the pathogenesis of sepsis. Potent action of adenosine in inhibiting cytotoxic PMN functions has been documented. Recent data, however provide evidence that in sepsis a dimini...

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Detalles Bibliográficos
Autores principales:	Kreth, Simone, Kaufmann, Ines, Ledderose, Carola, Luchting, Benjamin, Thiel, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823413/ https://www.ncbi.nlm.nih.gov/pubmed/19538256 http://dx.doi.org/10.1111/j.1582-4934.2008.00530.x

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