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Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke
Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic fact...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823421/ https://www.ncbi.nlm.nih.gov/pubmed/22452968 http://dx.doi.org/10.1111/j.1582-4934.2012.01575.x |
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author | Gutiérrez-Fernández, María Fuentes, Blanca Rodríguez-Frutos, Berta Ramos-Cejudo, Jaime Vallejo-Cremades, María Teresa Díez-Tejedor, Exuperio |
author_facet | Gutiérrez-Fernández, María Fuentes, Blanca Rodríguez-Frutos, Berta Ramos-Cejudo, Jaime Vallejo-Cremades, María Teresa Díez-Tejedor, Exuperio |
author_sort | Gutiérrez-Fernández, María |
collection | PubMed |
description | Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here. |
format | Online Article Text |
id | pubmed-3823421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38234212015-03-27 Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke Gutiérrez-Fernández, María Fuentes, Blanca Rodríguez-Frutos, Berta Ramos-Cejudo, Jaime Vallejo-Cremades, María Teresa Díez-Tejedor, Exuperio J Cell Mol Med Reviews Brain repair involves a compendium of natural mechanisms that are activated following stroke. From a therapeutic viewpoint, reparative therapies that encourage cerebral plasticity are needed. In the last years, it has been demonstrated that modulatory treatments for brain repair such as trophic factor- and stem cell-based therapies can promote neurogenesis, gliogenesis, oligodendrogenesis, synaptogenesis and angiogenesis, all of which having a beneficial impact on infarct volume, cell death and, finally, and most importantly, on the functional recovery. However, even when promising results have been obtained in a wide range of experimental animal models and conditions these preliminary results have not yet demonstrated their clinical efficacy. Here, we focus on brain repair modulatory treatments for ischaemic stroke, that use trophic factors, drugs with trophic effects and stem cell therapy. Important and still unanswered questions for translational research ranging from experimental animal models to recent and ongoing clinical trials are reviewed here. Blackwell Publishing Ltd 2012-10 2012-09-26 /pmc/articles/PMC3823421/ /pubmed/22452968 http://dx.doi.org/10.1111/j.1582-4934.2012.01575.x Text en Copyright © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Reviews Gutiérrez-Fernández, María Fuentes, Blanca Rodríguez-Frutos, Berta Ramos-Cejudo, Jaime Vallejo-Cremades, María Teresa Díez-Tejedor, Exuperio Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title | Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title_full | Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title_fullStr | Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title_full_unstemmed | Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title_short | Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
title_sort | trophic factors and cell therapy to stimulate brain repair after ischaemic stroke |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823421/ https://www.ncbi.nlm.nih.gov/pubmed/22452968 http://dx.doi.org/10.1111/j.1582-4934.2012.01575.x |
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