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Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy
Malignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823475/ https://www.ncbi.nlm.nih.gov/pubmed/18031298 http://dx.doi.org/10.1111/j.1582-4934.2007.00153.x |
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author | Knizetova, Petra Darling, John L Bartek, Jiri |
author_facet | Knizetova, Petra Darling, John L Bartek, Jiri |
author_sort | Knizetova, Petra |
collection | PubMed |
description | Malignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently focused on candidate cancer stem cells, their biological properties, interplay with their local microenvironment or ‘niche’ and their role in tumour progression and recurrence. Both paracrine and autocrine regulation of astroglioma cell behaviour by locally produced cytokines such as the vascular endothelial growth factor (VEGF) are emerging as key factors that determine astroglioma cell fate. Here, we review these recent rapid advances in astroglioma research, with emphasis on the significance of VEGF in astroglioma stem-like cell biology. Furthermore, we highlight the unique DNA damage checkpoint properties of the CD133-marker-positive astroglioma stem-like cells, discuss their potential involvement in astroglioma radioresistance and consider the implications of this new knowledge for designing combinatorial, more efficient therapeutic strategies. |
format | Online Article Text |
id | pubmed-3823475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38234752015-04-27 Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy Knizetova, Petra Darling, John L Bartek, Jiri J Cell Mol Med Reviews Malignant astrogliomas are among the most aggressive, highly vascular and infiltrating tumours bearing a dismal prognosis, mainly due to their resistance to current radiation treatment and chemotherapy. Efforts to identify and target the mechanisms that underlie astroglioma resistance have recently focused on candidate cancer stem cells, their biological properties, interplay with their local microenvironment or ‘niche’ and their role in tumour progression and recurrence. Both paracrine and autocrine regulation of astroglioma cell behaviour by locally produced cytokines such as the vascular endothelial growth factor (VEGF) are emerging as key factors that determine astroglioma cell fate. Here, we review these recent rapid advances in astroglioma research, with emphasis on the significance of VEGF in astroglioma stem-like cell biology. Furthermore, we highlight the unique DNA damage checkpoint properties of the CD133-marker-positive astroglioma stem-like cells, discuss their potential involvement in astroglioma radioresistance and consider the implications of this new knowledge for designing combinatorial, more efficient therapeutic strategies. Blackwell Publishing Ltd 2008-01 2007-11-20 /pmc/articles/PMC3823475/ /pubmed/18031298 http://dx.doi.org/10.1111/j.1582-4934.2007.00153.x Text en 2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd |
spellingShingle | Reviews Knizetova, Petra Darling, John L Bartek, Jiri Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title | Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title_full | Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title_fullStr | Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title_full_unstemmed | Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title_short | Vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
title_sort | vascular endothelial growth factor in astroglioma stem cell biology and response to therapy |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823475/ https://www.ncbi.nlm.nih.gov/pubmed/18031298 http://dx.doi.org/10.1111/j.1582-4934.2007.00153.x |
work_keys_str_mv | AT knizetovapetra vascularendothelialgrowthfactorinastrogliomastemcellbiologyandresponsetotherapy AT darlingjohnl vascularendothelialgrowthfactorinastrogliomastemcellbiologyandresponsetotherapy AT bartekjiri vascularendothelialgrowthfactorinastrogliomastemcellbiologyandresponsetotherapy |