Guanylate Cyclase C Deficiency Causes Severe Inflammation in a Murine Model of Spontaneous Colitis

BACKGROUND: Guanylate Cyclase C (GC-C; Gucy2c) is a transmembrane receptor expressed in intestinal epithelial cells. Activation of GC-C by its secreted ligand guanylin stimulates intestinal fluid secretion. Familial mutations in GC-C cause chronic diarrheal disease or constipation and are associated...

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Detalles Bibliográficos
Autores principales: Harmel-Laws, Eleana, Mann, Elizabeth A., Cohen, Mitchell B., Steinbrecher, Kris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823613/
https://www.ncbi.nlm.nih.gov/pubmed/24244444
http://dx.doi.org/10.1371/journal.pone.0079180

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