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TAP Mediates Import of Mycobacterium tuberculosis-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I
Processing and presentation of antigen on MHC-I class I molecules serves to present peptides derived from cytosolic proteins to CD8(+) T cells. Infection with bacteria that remain in phagosomal compartments, such as Mycobacterium tuberculosis (Mtb), provides a challenge to this immune recognition as...
Autores principales: | Harriff, Melanie J., Burgdorf, Sven, Kurts, Christian, Wiertz, Emmanuel J. H. J., Lewinsohn, Deborah A., Lewinsohn, David M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823705/ https://www.ncbi.nlm.nih.gov/pubmed/24244525 http://dx.doi.org/10.1371/journal.pone.0079571 |
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