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P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence

Persistent DNA damage triggers cellular senescence, which may play an important role in the pathogenesis of cigarette smoke (CS)-induced lung diseases. Both p21(CDKN1A) (p21) and poly(ADP-ribose) polymerase-1 (PARP-1) are involved in DNA damage and repair. However, the role of p21-PARP-1 axis in reg...

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Detalles Bibliográficos
Autores principales:	Yao, Hongwei, Sundar, Isaac K., Gorbunova, Vera, Rahman, Irfan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823706/ https://www.ncbi.nlm.nih.gov/pubmed/24244594 http://dx.doi.org/10.1371/journal.pone.0080007

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