Genetic and Acute CPEB Depletion Ameliorate Fragile X Pathophysiology

Fragile X Syndrome (FXS), the most common cause of inherited mental retardation and autism, is caused by transcriptional silencing of Fmr1, which encodes the translational repressor protein FMRP. FMRP and CPEB, an activator of translation, are present in neuronal dendrites, are predicted to bind man...

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Detalles Bibliográficos
Autores principales: Udagawa, Tsuyoshi, Farny, Natalie G., Jakovcevski, Mira, Kaphzan, Hanoch, Alarcon, Juan Marcos, Anilkumar, Shobha, Ivshina, Maria, Hurt, Jessica A., Nagaoka, Kentaro, Nalavadi, Vijayalaxmi C., Lorenz, Lori J., Bassell, Gary J., Akbarian, Schahram, Chattarji, Sumantra, Klann, Eric, Richter, Joel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823751/
https://www.ncbi.nlm.nih.gov/pubmed/24141422
http://dx.doi.org/10.1038/nm.3353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823751/
https://www.ncbi.nlm.nih.gov/pubmed/24141422
http://dx.doi.org/10.1038/nm.3353

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