Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

Globally, about 1% of pregnant women are persistently infected with the hepatitis C virus (HCV)(1). Vertical transmission occurs in 3–5% of cases(2) and accounts for most new childhood HCV infections(1,3). HCV-specific CD8(+) cytotoxic T-lymphocytes (CTLs) play a vital role in the clearance of acute...

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Detalles Bibliográficos
Autores principales: Honegger, Jonathan R., Kim, Seungtaek, Price, Aryn A., Kohout, Jennifer A., McKnight, Kevin L., Prasad, Mona R., Lemon, Stanley M., Grakoui, Arash, Walker, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823809/
https://www.ncbi.nlm.nih.gov/pubmed/24162814
http://dx.doi.org/10.1038/nm.3351

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