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MicroRNA-138 Regulates Hypoxia-Induced Endothelial Cell Dysfunction By Targeting S100A1

The Ca(2+) sensor S100A1 is essential for proper endothelial cell (EC) nitric oxide (NO) synthase (eNOS) activation. S100A1 levels are greatly reduced in primary human microvascular ECs subjected to hypoxia, rendering them dysfunctional. However mechanisms that regulate S100A1 levels in ECs are unkn...

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Detalles Bibliográficos
Autores principales: Sen, Anagha, Ren, Shumei, Lerchenmüller, Carolin, Sun, Jianxin, Weiss, Norbert, Most, Patrick, Peppel, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823839/
https://www.ncbi.nlm.nih.gov/pubmed/24244340
http://dx.doi.org/10.1371/journal.pone.0078684