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Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer

The development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The pu...

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Autores principales: Lelong, Nicolas, Vecellio, Laurent, Sommer de Gélicourt, Yann, Tanguy, Christian, Diot, Patrice, Junqua-Moullet, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823843/
https://www.ncbi.nlm.nih.gov/pubmed/24244334
http://dx.doi.org/10.1371/journal.pone.0078659
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author Lelong, Nicolas
Vecellio, Laurent
Sommer de Gélicourt, Yann
Tanguy, Christian
Diot, Patrice
Junqua-Moullet, Alexandra
author_facet Lelong, Nicolas
Vecellio, Laurent
Sommer de Gélicourt, Yann
Tanguy, Christian
Diot, Patrice
Junqua-Moullet, Alexandra
author_sort Lelong, Nicolas
collection PubMed
description The development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The purpose of this study is to design a numerical model simulating the nebulization process and to compare it with experimental data. Such a model could provide a better understanding of the atomization process and the parameters influencing the nebulizer output. A model based on the Updraft nebulizer (Hudson) was designed with ANSYS Workbench. Boundary conditions were set with experimental data then transient 3D calculations were run on a 4 µm mesh with ANSYS Fluent. Two air flow rate (2 L/min and 8 L/min, limits of the operating range) were considered to account for different turbulence regimes. Numerical and experimental results were compared according to phenomenology and droplet size. The behavior of the liquid was compared to images acquired through shadowgraphy with a CCD Camera. Three experimental methods, laser diffractometry, phase Doppler anemometry (PDA) and shadowgraphy were used to characterize the droplet size distributions. Camera images showed similar patterns as numerical results. Droplet sizes obtained numerically are overestimated in relation to PDA and diffractometry, which only consider spherical droplets. However, at both flow rates, size distributions extracted from numerical image processing were similar to distributions obtained from shadowgraphy image processing. The simulation then provides a good understanding and prediction of the phenomena involved in the fragmentation of droplets over 10 µm. The laws of dynamics apply to droplets down to 1 µm, so we can assume the continuity of the distribution and extrapolate the results for droplets between 1 and 10 µm. So, this model could help predicting nebulizer output with defined geometrical and physical parameters.
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spelling pubmed-38238432013-11-15 Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer Lelong, Nicolas Vecellio, Laurent Sommer de Gélicourt, Yann Tanguy, Christian Diot, Patrice Junqua-Moullet, Alexandra PLoS One Research Article The development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The purpose of this study is to design a numerical model simulating the nebulization process and to compare it with experimental data. Such a model could provide a better understanding of the atomization process and the parameters influencing the nebulizer output. A model based on the Updraft nebulizer (Hudson) was designed with ANSYS Workbench. Boundary conditions were set with experimental data then transient 3D calculations were run on a 4 µm mesh with ANSYS Fluent. Two air flow rate (2 L/min and 8 L/min, limits of the operating range) were considered to account for different turbulence regimes. Numerical and experimental results were compared according to phenomenology and droplet size. The behavior of the liquid was compared to images acquired through shadowgraphy with a CCD Camera. Three experimental methods, laser diffractometry, phase Doppler anemometry (PDA) and shadowgraphy were used to characterize the droplet size distributions. Camera images showed similar patterns as numerical results. Droplet sizes obtained numerically are overestimated in relation to PDA and diffractometry, which only consider spherical droplets. However, at both flow rates, size distributions extracted from numerical image processing were similar to distributions obtained from shadowgraphy image processing. The simulation then provides a good understanding and prediction of the phenomena involved in the fragmentation of droplets over 10 µm. The laws of dynamics apply to droplets down to 1 µm, so we can assume the continuity of the distribution and extrapolate the results for droplets between 1 and 10 µm. So, this model could help predicting nebulizer output with defined geometrical and physical parameters. Public Library of Science 2013-11-11 /pmc/articles/PMC3823843/ /pubmed/24244334 http://dx.doi.org/10.1371/journal.pone.0078659 Text en © 2013 Lelong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lelong, Nicolas
Vecellio, Laurent
Sommer de Gélicourt, Yann
Tanguy, Christian
Diot, Patrice
Junqua-Moullet, Alexandra
Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title_full Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title_fullStr Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title_full_unstemmed Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title_short Comparison of Numerical Simulations to Experiments for Atomization in a Jet Nebulizer
title_sort comparison of numerical simulations to experiments for atomization in a jet nebulizer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823843/
https://www.ncbi.nlm.nih.gov/pubmed/24244334
http://dx.doi.org/10.1371/journal.pone.0078659
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