Cargando…

A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

BACKGROUND: Ad35.CS.01 is a pre-erythrocytic malaria candidate vaccine. It is a codon optimized nucleotide sequence representing the P. falciparum circumsporozoite (CS) surface antigen inserted in a replication deficient Adenovirus 35 backbone. A Phase 1a trial has been conducted in the USA in naïve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ouédraogo, Alphonse, Tiono, Alfred B., Kargougou, Désiré, Yaro, Jean Baptiste, Ouédraogo, Esperance, Kaboré, Youssouf, Kangoye, David, Bougouma, Edith C., Gansane, Adama, Henri, Noelie, Diarra, Amidou, Sanon, Souleymane, Soulama, Issiaka, Konate, Amadou T., Watson, Nora L., Brown, Valerie, Hendriks, Jenny, Pau, Maria Grazia, Versteege, Isabella, Wiesken, Edison, Sadoff, Jerald, Nebie, Issa, Sirima, Sodiomon B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823848/ https://www.ncbi.nlm.nih.gov/pubmed/24244339 http://dx.doi.org/10.1371/journal.pone.0078679

Ejemplares similares

Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children
por: Sirima, Sodiomon B., et al.
Publicado: (2009)

Correction: Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children
por: Sirima, Sodiomon B., et al.
Publicado: (2010)

Seasonal performance of a malaria rapid diagnosis test at community health clinics in a malaria-hyperendemic region of Burkina Faso
por: Diarra, Amidou, et al.
Publicado: (2012)

Variation in haematological parameters in children less than five years of age with asymptomatic Plasmodium infection: implication for malaria field studies
por: Gansane, Adama, et al.
Publicado: (2013)

Malaria Morbidity in High and Seasonal Malaria Transmission Area of Burkina Faso
por: Ouédraogo, Alphonse, et al.
Publicado: (2013)

Haemoglobin variants and Plasmodium falciparum malaria in children under five years of age living in a high and seasonal malaria transmission area of Burkina Faso
por: Bougouma, Edith C, et al.
Publicado: (2012)

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children
por: Bougouma, Edith Christiane, et al.
Publicado: (2022)

Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Burkina Faso: A Randomised, Double-Blind, Placebo-Controlled Trial
por: Konaté, Amadou T., et al.
Publicado: (2011)

Malaria Incidence in Children in South-West Burkina Faso: Comparison of Active and Passive Case Detection Methods
por: Tiono, Alfred B., et al.
Publicado: (2014)

Morbidity from Malaria in Children in the Year after They Had Received Intermittent Preventive Treatment of Malaria: A Randomised Trial
por: Konaté, Amadou T., et al.
Publicado: (2011)

Plasmodium falciparum genotypes diversity in symptomatic malaria of children living in an urban and a rural setting in Burkina Faso
por: Soulama, Issiaka, et al.
Publicado: (2009)

Clinical Variation of Plasmodium falciparum eba-175, ama-1, and msp-3 Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso
por: Soulama, Issiaka, et al.
Publicado: (2015)

Plasmodium falciparum Malaria in Children Aged 0-2 Years: The Role of Foetal Haemoglobin and Maternal Antibodies to Two Asexual Malaria Vaccine Candidates (MSP3 and GLURP)
por: Kangoye, David Tiga, et al.
Publicado: (2014)

Hospital-based surveillance of severe paediatric malaria in two malaria transmission ecological zones of Burkina Faso
por: Tiono, Alfred B., et al.
Publicado: (2023)

Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe children
por: Tiono, Alfred B., et al.
Publicado: (2023)

Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial
por: Ouédraogo, Alphonse, et al.
Publicado: (2023)

Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
por: Diarra, Amidou, et al.
Publicado: (2012)

Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens
por: Tiono, Alfred B, et al.
Publicado: (2009)

Transplacental Transmission of Plasmodium falciparum in a Highly Malaria Endemic Area of Burkina Faso
por: Ouédraogo, Alphonse, et al.
Publicado: (2012)

Risk factors for Plasmodium falciparum infection in pregnant women in Burkina Faso: a community-based cross-sectional survey
por: Yaro, Jean Baptiste, et al.
Publicado: (2021)

Lessons learned from the use of HRP-2 based rapid diagnostic test in community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso
por: Tiono, Alfred B, et al.
Publicado: (2014)

Humoral and cell-mediated immunity to MSP3 peptides in adults immunized with MSP3 in malaria endemic area, Burkina Faso
por: NEBIE, I, et al.
Publicado: (2009)

Malariometric Indices in the Context of Seasonal Malaria Chemoprevention in Children Aged 1.5 to 12 Years during the Period of High Malaria Transmission in the Suburban Area of Banfora, Burkina Faso
por: Ouattara, San M., et al.
Publicado: (2023)

A cohort study to identify risk factors for Plasmodium falciparum infection in Burkinabe children: implications for other high burden high impact countries
por: Yaro, Jean Baptiste, et al.
Publicado: (2020)

Low Specificity of a Malaria Rapid Diagnostic Test During an Integrated Community Case Management Trial
por: Tiono, Alfred B., et al.
Publicado: (2013)

Erratum to: Low Specificity of a Malaria Rapid Diagnostic Test During an Integrated Community Case Management Trial
por: Tiono, Alfred B., et al.
Publicado: (2013)

In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso
por: Sanon, Souleymane, et al.
Publicado: (2013)

Contribution of the Rapid LAMP-Based Diagnostic Test (RLDT) to the Evaluation of Enterotoxigenic Escherichia coli (ETEC) and Shigella in Childhood Diarrhea in the Peri-Urban Area of Ouagadougou, Burkina Faso
por: Héma, Alimatou, et al.
Publicado: (2023)

Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa
por: B. Henry, Noëlie, et al.
Publicado: (2023)

The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum
por: Sirima, Sodiomon B, et al.
Publicado: (2009)

Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of P. falciparum Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa
por: Nikiema, Séni, et al.
Publicado: (2022)

A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso
por: Tiono, Alfred B, et al.
Publicado: (2013)

Safety and immunogenicity of Vi-typhoid conjugate vaccine co-administration with routine 9-month vaccination in Burkina Faso: A randomized controlled phase 2 trial
por: Sirima, Sodiomon B., et al.
Publicado: (2021)

Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso
por: Sanou, Guillaume S, et al.
Publicado: (2012)

Safety and immunogenicity of co-administration of meningococcal type A and measles–rubella vaccines with typhoid conjugate vaccine in children aged 15–23 months in Burkina Faso
por: Sirima, Sodiomon B., et al.
Publicado: (2021)

Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections
por: Barry, Aissata, et al.
Publicado: (2021)

Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission
por: Henry, Noëlie Béré, et al.
Publicado: (2019)

Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso
por: Morter, Richard, et al.
Publicado: (2022)

First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children
por: Tiono, Alfred B., et al.
Publicado: (2018)

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial
por: Gonçalves, Bronner P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7mj8apslu04e6ijkuviu20femq