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Does Cognitive Function Increase over Time in the Healthy Elderly?

BACKGROUND: In dementia screening, most studies have focused on early cognitive impairment by comparing patients suffering from mild dementia or mild cognitive impairment with normal subjects. Few studies have focused on modifications over time of the cognitive function in the healthy elderly. The o...

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Autores principales: de Rotrou, Jocelyne, Wu, Ya-Huei, Mabire, Jean-Bernard, Moulin, Florence, de Jong, Laura W., Rigaud, Anne-Sophie, Hanon, Olivier, Vidal, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823862/
https://www.ncbi.nlm.nih.gov/pubmed/24244332
http://dx.doi.org/10.1371/journal.pone.0078646
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author de Rotrou, Jocelyne
Wu, Ya-Huei
Mabire, Jean-Bernard
Moulin, Florence
de Jong, Laura W.
Rigaud, Anne-Sophie
Hanon, Olivier
Vidal, Jean-Sébastien
author_facet de Rotrou, Jocelyne
Wu, Ya-Huei
Mabire, Jean-Bernard
Moulin, Florence
de Jong, Laura W.
Rigaud, Anne-Sophie
Hanon, Olivier
Vidal, Jean-Sébastien
author_sort de Rotrou, Jocelyne
collection PubMed
description BACKGROUND: In dementia screening, most studies have focused on early cognitive impairment by comparing patients suffering from mild dementia or mild cognitive impairment with normal subjects. Few studies have focused on modifications over time of the cognitive function in the healthy elderly. The objective of the present study was to analyze the cognitive function changes of two different samples, born > 15 years apart. METHOD: A first sample of 204 cognitively normal participants was recruited in the memory clinic of Broca hospital between 1991 and 1997. A second sample of 177 cognitively normal participants was recruited in 2008–2009 in the same institution. Both samples were from the same districts of Paris and were assessed with the same neuropsychological test battery. Mean cognitive test scores were compared between 1991 and 2008 samples, between < 80 years old and ≥ 80 years old in 1991 and 2008 samples, and finally between subjects < 80 year old of 1991 sample and subjects ≥ 80 years old of the 2008 sample. Means were compared with T-tests stratified on gender, age-groups and educational level. RESULTS: Cognitive scores were significantly higher in the 2008 sample. Participants < 80 years old outperformed those ≥ 80 in both samples. However, participants < 80 years old in 1991 sample and subjects ≥ 80 in the 2008 sample, born on average in 1923, performed mostly identically. CONCLUSION: This study showed a significant increase of cognitive scores over time. Further, contemporary octogenarians in the later sample performed like septuagenarians in the former sample. These findings might be consistent with the increase in life expectancy and life span in good health. The study highlights the necessity to take into account factors which may contaminate and artificially inflate the age-related differences in favor of younger to the older adults.
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spelling pubmed-38238622013-11-15 Does Cognitive Function Increase over Time in the Healthy Elderly? de Rotrou, Jocelyne Wu, Ya-Huei Mabire, Jean-Bernard Moulin, Florence de Jong, Laura W. Rigaud, Anne-Sophie Hanon, Olivier Vidal, Jean-Sébastien PLoS One Research Article BACKGROUND: In dementia screening, most studies have focused on early cognitive impairment by comparing patients suffering from mild dementia or mild cognitive impairment with normal subjects. Few studies have focused on modifications over time of the cognitive function in the healthy elderly. The objective of the present study was to analyze the cognitive function changes of two different samples, born > 15 years apart. METHOD: A first sample of 204 cognitively normal participants was recruited in the memory clinic of Broca hospital between 1991 and 1997. A second sample of 177 cognitively normal participants was recruited in 2008–2009 in the same institution. Both samples were from the same districts of Paris and were assessed with the same neuropsychological test battery. Mean cognitive test scores were compared between 1991 and 2008 samples, between < 80 years old and ≥ 80 years old in 1991 and 2008 samples, and finally between subjects < 80 year old of 1991 sample and subjects ≥ 80 years old of the 2008 sample. Means were compared with T-tests stratified on gender, age-groups and educational level. RESULTS: Cognitive scores were significantly higher in the 2008 sample. Participants < 80 years old outperformed those ≥ 80 in both samples. However, participants < 80 years old in 1991 sample and subjects ≥ 80 in the 2008 sample, born on average in 1923, performed mostly identically. CONCLUSION: This study showed a significant increase of cognitive scores over time. Further, contemporary octogenarians in the later sample performed like septuagenarians in the former sample. These findings might be consistent with the increase in life expectancy and life span in good health. The study highlights the necessity to take into account factors which may contaminate and artificially inflate the age-related differences in favor of younger to the older adults. Public Library of Science 2013-11-11 /pmc/articles/PMC3823862/ /pubmed/24244332 http://dx.doi.org/10.1371/journal.pone.0078646 Text en © 2013 de Rotrou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
de Rotrou, Jocelyne
Wu, Ya-Huei
Mabire, Jean-Bernard
Moulin, Florence
de Jong, Laura W.
Rigaud, Anne-Sophie
Hanon, Olivier
Vidal, Jean-Sébastien
Does Cognitive Function Increase over Time in the Healthy Elderly?
title Does Cognitive Function Increase over Time in the Healthy Elderly?
title_full Does Cognitive Function Increase over Time in the Healthy Elderly?
title_fullStr Does Cognitive Function Increase over Time in the Healthy Elderly?
title_full_unstemmed Does Cognitive Function Increase over Time in the Healthy Elderly?
title_short Does Cognitive Function Increase over Time in the Healthy Elderly?
title_sort does cognitive function increase over time in the healthy elderly?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823862/
https://www.ncbi.nlm.nih.gov/pubmed/24244332
http://dx.doi.org/10.1371/journal.pone.0078646
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