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Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats
In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID(50) was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omep...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823953/ https://www.ncbi.nlm.nih.gov/pubmed/24227941 http://dx.doi.org/10.4196/kjpp.2013.17.5.411 |
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author | Im, Wi Joon Nam, Yoonjin Park, Sun Young Sohn, Uy Dong |
author_facet | Im, Wi Joon Nam, Yoonjin Park, Sun Young Sohn, Uy Dong |
author_sort | Im, Wi Joon |
collection | PubMed |
description | In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID(50) was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each ID(50) was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats. |
format | Online Article Text |
id | pubmed-3823953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38239532013-11-13 Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats Im, Wi Joon Nam, Yoonjin Park, Sun Young Sohn, Uy Dong Korean J Physiol Pharmacol Original Article In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID(50) was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each ID(50) was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats. The Korean Physiological Society and The Korean Society of Pharmacology 2013-10 2013-10-17 /pmc/articles/PMC3823953/ /pubmed/24227941 http://dx.doi.org/10.4196/kjpp.2013.17.5.411 Text en Copyright © 2013 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Im, Wi Joon Nam, Yoonjin Park, Sun Young Sohn, Uy Dong Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title | Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title_full | Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title_fullStr | Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title_full_unstemmed | Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title_short | Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats |
title_sort | gastroprotective effect of the three glucuronopyranoside flavonoids in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823953/ https://www.ncbi.nlm.nih.gov/pubmed/24227941 http://dx.doi.org/10.4196/kjpp.2013.17.5.411 |
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