Normal Hematopoietic Stem Cells within the AML Bone Marrow Have a Distinct and Higher ALDH Activity Level than Co-Existing Leukemic Stem Cells

Persistence of leukemic stem cells (LSC) after chemotherapy is thought to be responsible for relapse and prevents the curative treatment of acute myeloid leukemia (AML) patients. LSC and normal hematopoietic stem cells (HSC) share many characteristics and co-exist in the bone marrow of AML patients....

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Detalles Bibliográficos
Autores principales: Schuurhuis, Gerrit J., Meel, Michael H., Wouters, Floris, Min, Lisa A., Terwijn, Monique, de Jonge, Nick A., Kelder, Angele, Snel, Alexander N., Zweegman, Sonja, Ossenkoppele, Gert J., Smit, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823975/
https://www.ncbi.nlm.nih.gov/pubmed/24244383
http://dx.doi.org/10.1371/journal.pone.0078897

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