Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide

Senataxin is a large 303 kDa protein linked to neuron survival, as recessive mutations cause Ataxia with Oculomotor Apraxia type 2 (AOA2), and dominant mutations cause amyotrophic lateral sclerosis type 4 (ALS4). Senataxin contains an amino-terminal protein-interaction domain and a carboxy-terminal...

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Detalles Bibliográficos
Autores principales: Bennett, Craig L., Chen, Yingzhang, Vignali, Marissa, Lo, Russell S., Mason, Amanda G., Unal, Asli, Huq Saifee, Nabiha P., Fields, Stanley, La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823977/
https://www.ncbi.nlm.nih.gov/pubmed/24244371
http://dx.doi.org/10.1371/journal.pone.0078837

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