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Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis

Cellular cholesterol levels are controlled by endoplasmic reticulum (ER) sterol sensing proteins, which include Scap and Insig-1. With cholesterol sufficiency, Insig inhibits the activation of sterol regulatory element binding proteins (SREBPs), key transcription factors for cholesterol and fatty ac...

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Detalles Bibliográficos
Autores principales:	Huber, Michael D., Vesely, Paul W., Datta, Kaustuv, Gerace, Larry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824017/ https://www.ncbi.nlm.nih.gov/pubmed/24217618 http://dx.doi.org/10.1083/jcb.201305076

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