A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation

DNA topoisomerase IIα (Topo IIα) is the target of an important class of anticancer drugs, but tumor cells can become resistant by reducing the association of the enzyme with chromosomes. Here we describe a critical mechanism of chromatin recruitment and exchange that relies on a novel chromatin teth...

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Detalles Bibliográficos
Autores principales: Lane, Andrew B., Giménez-Abián, Juan F., Clarke, Duncan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824022/
https://www.ncbi.nlm.nih.gov/pubmed/24217621
http://dx.doi.org/10.1083/jcb.201303045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824022/
https://www.ncbi.nlm.nih.gov/pubmed/24217621
http://dx.doi.org/10.1083/jcb.201303045

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