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A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation
DNA topoisomerase IIα (Topo IIα) is the target of an important class of anticancer drugs, but tumor cells can become resistant by reducing the association of the enzyme with chromosomes. Here we describe a critical mechanism of chromatin recruitment and exchange that relies on a novel chromatin teth...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824022/ https://www.ncbi.nlm.nih.gov/pubmed/24217621 http://dx.doi.org/10.1083/jcb.201303045 |