Combination of pharmacophore hypothesis, genetic function approximation model, and molecular docking to identify novel inhibitors of S6K1

S6K1 has emerged as a potential target for the treatment for obesity, type II diabetes and cancer diseases. Discovery of S6K1 inhibitors has thus attracted much attention in recent years. In this investigation, a hybrid virtual screening method that involves pharmacophore hypothesis, genetic functio...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Xiang, Ming-Li, Liang, Jun-Yu, Zeng, Tao, Zhang, Xiao-Nuo, Zhang, Ji, Yang, Sheng-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Full-Length Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824193/
https://www.ncbi.nlm.nih.gov/pubmed/23982212
http://dx.doi.org/10.1007/s11030-013-9473-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824193/
https://www.ncbi.nlm.nih.gov/pubmed/23982212
http://dx.doi.org/10.1007/s11030-013-9473-7

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