A phase 2 study of everolimus combined with trastuzumab and paclitaxel in patients with HER2-overexpressing advanced breast cancer that progressed during prior trastuzumab and taxane therapy

Increased activation of the PI3K/Akt/mTOR pathway is a common factor in putative mechanisms of trastuzumab resistance, resulting in dysregulation of cell migration, growth, proliferation, and survival. Data from preclinical and phase 1/2 clinical studies suggest that adding everolimus (an oral mTOR...

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Detalles Bibliográficos
Autores principales: Hurvitz, Sara A., Dalenc, Florence, Campone, Mario, O’Regan, Ruth M., Tjan-Heijnen, Vivianne C., Gligorov, Joseph, Llombart, Antonio, Jhangiani, Haresh, Mirshahidi, Hamid R., Tan-Chiu, Elizabeth, Miao, Sara, El-Hashimy, Mona, Lincy, Jeremie, Taran, Tetiana, Soria, Jean-Charles, Sahmoud, Tarek, André, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824346/
https://www.ncbi.nlm.nih.gov/pubmed/24101324
http://dx.doi.org/10.1007/s10549-013-2689-5

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