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Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy

Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods....

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Autores principales: Simic Ogrizovic, Sanja, Bojic, Suzana, Basta-Jovanovic, Gordana, Radojevic, Sanja, Pavlovic, Jelena, Kotur Stevuljevic, Jelena, Dopsaj, Violeta, Naumovic, Radomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824354/
https://www.ncbi.nlm.nih.gov/pubmed/24282337
http://dx.doi.org/10.1155/2013/183246
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author Simic Ogrizovic, Sanja
Bojic, Suzana
Basta-Jovanovic, Gordana
Radojevic, Sanja
Pavlovic, Jelena
Kotur Stevuljevic, Jelena
Dopsaj, Violeta
Naumovic, Radomir
author_facet Simic Ogrizovic, Sanja
Bojic, Suzana
Basta-Jovanovic, Gordana
Radojevic, Sanja
Pavlovic, Jelena
Kotur Stevuljevic, Jelena
Dopsaj, Violeta
Naumovic, Radomir
author_sort Simic Ogrizovic, Sanja
collection PubMed
description Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later. Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = −0.572), GFR6 (r = −0.442), GFR24 (r = −0.398), and GFR36 (r = −0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
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spelling pubmed-38243542013-11-26 Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy Simic Ogrizovic, Sanja Bojic, Suzana Basta-Jovanovic, Gordana Radojevic, Sanja Pavlovic, Jelena Kotur Stevuljevic, Jelena Dopsaj, Violeta Naumovic, Radomir Dis Markers Research Article Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later. Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = −0.572), GFR6 (r = −0.442), GFR24 (r = −0.398), and GFR36 (r = −0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (P = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest. Hindawi Publishing Corporation 2013 2013-10-27 /pmc/articles/PMC3824354/ /pubmed/24282337 http://dx.doi.org/10.1155/2013/183246 Text en Copyright © 2013 Sanja Simic Ogrizovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Simic Ogrizovic, Sanja
Bojic, Suzana
Basta-Jovanovic, Gordana
Radojevic, Sanja
Pavlovic, Jelena
Kotur Stevuljevic, Jelena
Dopsaj, Violeta
Naumovic, Radomir
Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title_full Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title_fullStr Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title_full_unstemmed Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title_short Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
title_sort tissue kidney injury molecule-1 expression in the prediction of renal function for several years after kidney biopsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824354/
https://www.ncbi.nlm.nih.gov/pubmed/24282337
http://dx.doi.org/10.1155/2013/183246
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