DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals

Human-nucleotide-excision repair (NER) deficiency leads to different developmental and segmental progeroid symptoms of which the pathogenesis is only partially understood. To understand the biological impact of accumulating spontaneous DNA damage, we studied the phenotypic consequences of DNA-repair...

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Detalles Bibliográficos
Autores principales: Lans, H, Lindvall, J M, Thijssen, K, Karambelas, A E, Cupac, D, Fensgård, Ø, Jansen, G, Hoeijmakers, J H J, Nilsen, H, Vermeulen, W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824592/
https://www.ncbi.nlm.nih.gov/pubmed/24013725
http://dx.doi.org/10.1038/cdd.2013.126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824592/
https://www.ncbi.nlm.nih.gov/pubmed/24013725
http://dx.doi.org/10.1038/cdd.2013.126

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