Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells

Epithelial–mesenchymal transition (EMT) is a crucial step in tumor progression, and the TGFβ–SMAD signaling pathway as an inductor of EMT in many tumor types is well recognized. However, the role of non-canonical TGFβ–TAK1 signaling in EMT remains unclear. Herein, we show that TAK1 deficiency drives...

Descripción completa

Detalles Bibliográficos
Autores principales: Lam, C R I, Tan, C, Teo, Z, Tay, C Y, Phua, T, Wu, Y L, Cai, P Q, Tan, L P, Chen, X, Zhu, P, Tan, N S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824649/
https://www.ncbi.nlm.nih.gov/pubmed/24113182
http://dx.doi.org/10.1038/cddis.2013.339

Ejemplares similares

Ejemplares similares