Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1(G93A) model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of motor neurons, axon degeneration, and denervation of neuromuscular junctions (NMJ). Here we show that death receptor 6 (DR6) levels are elevated in spinal cords from post-mortem samples of human ALS and...

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Detalles Bibliográficos
Autores principales: Huang, G, Lee, X, Bian, Y, Shao, Z, Sheng, G, Pepinsky, R B, Mi, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824687/
https://www.ncbi.nlm.nih.gov/pubmed/24113175
http://dx.doi.org/10.1038/cddis.2013.378

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