Cargando…

Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge

Introduction. Granulocytic sarcoma (GS), also known as chloroma or extramedullary myeloblastoma, is a solid tumor composed of primitive precursors of the granulocytic series that include myeloblasts, promyelocytes, and myelocytes. Granulocytic sarcoma is a rare tumor that may develop during acute my...

Descripción completa

Detalles Bibliográficos
Autores principales: Elyamany, Ghaleb, Khan, Mohammed, El Hag, Imad, El-Zimaity, Maha, Albalawi, Mohamed, AL Abdulaaly, Abdulaziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824813/
https://www.ncbi.nlm.nih.gov/pubmed/24282418
http://dx.doi.org/10.1155/2013/483291
_version_ 1782290746353647616
author Elyamany, Ghaleb
Khan, Mohammed
El Hag, Imad
El-Zimaity, Maha
Albalawi, Mohamed
AL Abdulaaly, Abdulaziz
author_facet Elyamany, Ghaleb
Khan, Mohammed
El Hag, Imad
El-Zimaity, Maha
Albalawi, Mohamed
AL Abdulaaly, Abdulaziz
author_sort Elyamany, Ghaleb
collection PubMed
description Introduction. Granulocytic sarcoma (GS), also known as chloroma or extramedullary myeloblastoma, is a solid tumor composed of primitive precursors of the granulocytic series that include myeloblasts, promyelocytes, and myelocytes. Granulocytic sarcoma is a rare tumor that may develop during acute myeloid leukemia (AML) but less frequently may precede its presentation. Although generalized lymph node enlargement is a presentation for malignant lymphoma, it can also rarely be the early presenting sign of GS. Methods. We present a case of GS mimicking lymphoma in a 45-year-old male. The patient presented with bilateral neck masses and had widespread, prominent lymphadenopathy secondary to AML as the first presenting manifestation of GS for the last 4 months with concurrent marrow AML. Result. A clinical diagnosis of lymphoma was suspected; fine needle aspiration cytology findings were also suggestive of lymphoma. However, peripheral blood and bone marrow examination reported as acute myeloid leukemia with monocytic differentiation and histopathology of excised lymph node confirmed it to be a GS not lymphoma. Conclusion. GS is often misdiagnosed as malignant lymphoma because of cytomorphologic and histologic similarities of the blasts to large cell lymphoma. A careful search for immature myeloid is a useful clue to the diagnosis accompanied with appropriate immunophenotyping.
format Online
Article
Text
id pubmed-3824813
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-38248132013-11-26 Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge Elyamany, Ghaleb Khan, Mohammed El Hag, Imad El-Zimaity, Maha Albalawi, Mohamed AL Abdulaaly, Abdulaziz Case Rep Med Case Report Introduction. Granulocytic sarcoma (GS), also known as chloroma or extramedullary myeloblastoma, is a solid tumor composed of primitive precursors of the granulocytic series that include myeloblasts, promyelocytes, and myelocytes. Granulocytic sarcoma is a rare tumor that may develop during acute myeloid leukemia (AML) but less frequently may precede its presentation. Although generalized lymph node enlargement is a presentation for malignant lymphoma, it can also rarely be the early presenting sign of GS. Methods. We present a case of GS mimicking lymphoma in a 45-year-old male. The patient presented with bilateral neck masses and had widespread, prominent lymphadenopathy secondary to AML as the first presenting manifestation of GS for the last 4 months with concurrent marrow AML. Result. A clinical diagnosis of lymphoma was suspected; fine needle aspiration cytology findings were also suggestive of lymphoma. However, peripheral blood and bone marrow examination reported as acute myeloid leukemia with monocytic differentiation and histopathology of excised lymph node confirmed it to be a GS not lymphoma. Conclusion. GS is often misdiagnosed as malignant lymphoma because of cytomorphologic and histologic similarities of the blasts to large cell lymphoma. A careful search for immature myeloid is a useful clue to the diagnosis accompanied with appropriate immunophenotyping. Hindawi Publishing Corporation 2013 2013-10-27 /pmc/articles/PMC3824813/ /pubmed/24282418 http://dx.doi.org/10.1155/2013/483291 Text en Copyright © 2013 Ghaleb Elyamany et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Elyamany, Ghaleb
Khan, Mohammed
El Hag, Imad
El-Zimaity, Maha
Albalawi, Mohamed
AL Abdulaaly, Abdulaziz
Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title_full Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title_fullStr Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title_full_unstemmed Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title_short Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge
title_sort generalized lymphadenopathy as the first presentation of granulocytic sarcoma: a diagnostic challenge
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824813/
https://www.ncbi.nlm.nih.gov/pubmed/24282418
http://dx.doi.org/10.1155/2013/483291
work_keys_str_mv AT elyamanyghaleb generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge
AT khanmohammed generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge
AT elhagimad generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge
AT elzimaitymaha generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge
AT albalawimohamed generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge
AT alabdulaalyabdulaziz generalizedlymphadenopathyasthefirstpresentationofgranulocyticsarcomaadiagnosticchallenge