Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition

Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Byun, Hyun Jung, Kang, Kyung Jin, Park, Mi Kyung, Lee, Hye Ja, Kang, June Hee, Lee, Eun Ji, Kim, You Ri, Kim, Hyun Ji, Kim, Young Woo, Jung, Kyung Chae, Kim, Soo Youl, Lee, Chang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825196/
https://www.ncbi.nlm.nih.gov/pubmed/24244820
http://dx.doi.org/10.4062/biomolther.2013.066

Ejemplares similares

Ejemplares similares